García-Irizarry Kimberly D, Rojas-Brenes María E, Oliveras-Torres José A, Ortiz-Ortiz Camila N, Cress William D, Gordián Edna, Martínez Ricardo Gómez, Quintana-González Francisco J, Escobar-Rodríguez Pedro F, Muñoz-Antonia Teresita, Flores Idhaliz
Puerto Rico Biobank, Ponce Health Sciences University-Moffitt Cancer Center U54 Partnerships to Advance Cancer Health Equity (PACHE), Ponce, USA.
Department of Molecular Oncology, Moffitt Cancer Center, Tampa, FL, USA.
J Racial Ethn Health Disparities. 2025 Jan 20. doi: 10.1007/s40615-024-02267-8.
Incidence of endometrial cancer (EC) in Hispanic/Latina (H/L) women are higher compared to other race/ethnicities in the United States. EC is the third most common cancer and the fourth cause of cancer-related deaths in Puerto Rican women, yet demographic and clinical information is limited. High rates of EC risk factors such as obesity, diabetes mellitus type 2 (DM2) and hypertension (HTN) have been documented in the Puerto Rican population.
To describe the demographic, clinical history, lifestyle, obstetrical-gynecological, pathologic, and molecular profiles of women with EC predominantly from Southern/Central Puerto Rico.
We conducted a retrospective secondary analysis of data abstracted from the Puerto Rico Central Cancer Registry (PRCCR), self-administered questionnaires and medical records of EC cases. Descriptive statistics were conducted using SPSS V28 and RStudio.
We identified 105 EC cases aged 28-82. The major risk factors were BMI ≥ 30 (72%), HTN (33%), and DM2 (20%). Endometrioid adenocarcinoma was the main histological tumor type (80%), of which 74% were Type I. Obesity and nulliparity were associated with younger age at diagnosis. Older age at diagnosis (> 65 y/o) was associated with more advanced disease.
This study defined the clinical-demographic profile of women with EC from Puerto Rico and identified risks factors that are associated with younger or older age at diagnosis.
Profiling the risk factors for EC may help improve diagnostic accuracy and clinical management and result in better outcomes for this under-served, under-researched cancer patient population.
在美国，西班牙裔/拉丁裔（H/L）女性的子宫内膜癌（EC）发病率高于其他种族/族裔。EC是波多黎各女性中第三常见的癌症，也是癌症相关死亡的第四大原因，但人口统计学和临床信息有限。波多黎各人群中已记录到较高的EC风险因素发生率，如肥胖、2型糖尿病（DM2）和高血压（HTN）。
描述主要来自波多黎各南部/中部的EC女性的人口统计学、临床病史、生活方式、妇产科、病理和分子特征。
我们对从波多黎各中央癌症登记处（PRCCR）提取的数据、自我管理的问卷以及EC病例的医疗记录进行了回顾性二次分析。使用SPSS V28和RStudio进行描述性统计。
我们确定了105例年龄在28 - 82岁之间的EC病例。主要风险因素为BMI≥30（72%）、HTN（33%）和DM2（20%）。子宫内膜样腺癌是主要的组织学肿瘤类型（80%），其中74%为I型。肥胖和未生育与诊断时年龄较轻有关。诊断时年龄较大（>65岁）与疾病进展更严重有关。
本研究定义了波多黎各EC女性的临床人口统计学特征，并确定了与诊断时年龄较小或较大相关的风险因素。
分析EC的风险因素可能有助于提高诊断准确性和临床管理水平，并为这一服务不足、研究较少的癌症患者群体带来更好的治疗结果。
