Chen Qi, Tong Mancy, Guo Fang, Lau Sandy, Zhao Min
1. The Hospital of Obstetrics & Gynaecology, Fudan University, China ; 2. Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand.
2. Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand.
J Cancer. 2015 Sep 3;6(11):1087-92. doi: 10.7150/jca.12736. eCollection 2015.
Parity is one of well-known risk factors of endometrial cancer, but it is less clear whether parity is associated with the timing of developing endometrial cancer, and with the incidence of subtype of endometrial cancer. Data on 902 patients including age at diagnosis, age at menarche and menopause, parity and age at last birth from two obstetrics and gynaecology hospitals in China was analysed. 5.6% patients were nulliparous, 53.4% patients had one live birth, 27.7% patients had two live births and 13.3% patients had three or more live births. Patients at diagnosis who had three or more live births were significantly older than patients who were nulliparous or had one or two live births with the median age at diagnosis of 63 versus 51 or 52 or 59 years respectively. The percentage of patients with three or more live births at diagnosis before menopause was significantly lower than patients who were nulliparous, had one live birth or had two live births (10% versus 52%, or 51.9% or 22.4%). Furthermore, time from last birth to endometrial cancer was significantly longer in patients who had three or more live births than patients who had two live births or had one live birth (35 versus 31, or 24 years). However, there was no difference in the incidence of subtypes of endometrial cancer according to parity. Our data suggests parity is negatively correlated with the time onset of endometrial cancer and not associated with the incidence of endometrial cancer subtypes.
生育状况是子宫内膜癌众所周知的风险因素之一，但生育状况是否与子宫内膜癌的发病时间以及子宫内膜癌亚型的发病率相关尚不清楚。分析了来自中国两家妇产科医院的902例患者的数据，包括诊断时年龄、初潮和绝经年龄、生育状况以及最后一次生育时的年龄。5.6%的患者未生育，53.4%的患者有一次活产，27.7%的患者有两次活产，13.3%的患者有三次或更多次活产。诊断时生育三次或更多次的患者明显比未生育或有一两次活产的患者年龄大，诊断时的中位年龄分别为63岁，而未生育、有一次活产或有两次活产的患者分别为51岁、52岁或59岁。绝经前诊断时生育三次或更多次的患者百分比明显低于未生育、有一次活产或有两次活产的患者（10%对52%、51.9%或22.4%）。此外，生育三次或更多次的患者从最后一次生育到患子宫内膜癌的时间明显长于生育两次或有一次活产的患者（35年对31年或24年）。然而，根据生育状况，子宫内膜癌亚型的发病率没有差异。我们的数据表明，生育状况与子宫内膜癌的发病时间呈负相关，与子宫内膜癌亚型的发病率无关。
