在用司库奇尤单抗治疗的斑块状银屑病患者中，尽管避免接触温泉，仍出现复发性非结核分枝杆菌肺病：一例报告。
Recurrent NTM pulmonary disease despite avoidance of hot spring exposure in a plaque psoriasis patient treated with Secukinumab: a case report.
作者信息
Wei Yixiao, Wang Chunlei, Chong Lingtao, Cui Xiaojing
机构信息
Peking University Health Science Center, Beijing, 100191, China.
Laboratory of Clinical Microbiology and Infectious Diseases, China-Japan Friendship Hospital, Beijing, 100029, China.
出版信息
BMC Infect Dis. 2025 Jan 20;25(1):82. doi: 10.1186/s12879-025-10487-4.
BACKGROUND
Recurrent Non-Tuberculous Mycobacterial Pulmonary Disease (NTM-PD) related to treatment with Secukinumab has not been previously documented.
CASE PRESENTATION
Despite adherence to treatment and avoiding hot springs, a plaque psoriasis patient experienced persistent NTM-PD relapses.
CONCLUSIONS
There is potential association between Secukinumab, an IL-17A inhibitor, and NTM disease, echoing anti-TNF biologics' NTM risk, indicating the urgent need for further research on pathogenic mechanisms and risk factors.
背景
与司库奇尤单抗治疗相关的复发性非结核分枝杆菌肺病（NTM-PD）此前尚无文献记载。
病例报告
尽管坚持治疗并避免泡温泉，但一名斑块状银屑病患者仍经历了NTM-PD的持续复发。
结论
白细胞介素-17A抑制剂司库奇尤单抗与NTM疾病之间可能存在关联，这与抗TNF生物制剂的NTM风险相呼应，表明迫切需要对致病机制和危险因素进行进一步研究。
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