Ozel Elif Sarikaya, Kaya Cengiz, Turunc Esra, Ustun Yasemin B, Cebeci Halil, Dost Burhan
Department of Anesthesiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Korean J Anesthesiol. 2025 Apr;78(2):159-170. doi: 10.4097/kja.24569. Epub 2025 Jan 21.
Laparoscopic sleeve gastrectomy (LSG) causes significant postoperative pain, necessitating effective multimodal analgesia strategies. This study evaluated the efficacy of the external oblique intercostal block (EOIB) in this context.
This prospective, randomized, controlled, single-blind study conducted between April and December 2023 included 60 patients who underwent LSG. Patients were divided into the EOIB (30 ml 0.25% bupivacaine/side) and control (no block) groups. The primary outcome was the cumulative intravenous morphine milligram equivalent (MME) consumption in the first 24 h postoperatively. Secondary outcomes included 12-h MME consumption, pain scores, intraoperative remifentanil use, rescue analgesia requirements, time to first analgesic request, nausea/vomiting scores, antiemetic use, and American Pain Society Patient Outcome Questionnaire-Revised Turkish Version (APS-POQ-R-TR) scores.
The control group had significantly higher median opioid consumption than the EOIB group at 12 (14.4 vs. 5.8 mg; P < 0.001) and 24 h (25.9 vs. 10.6 mg; P < 0.001) postoperatively. The need for rescue analgesics did not differ significantly (43.3 vs. 23.3%; P = 0.1). The EOIB group exhibited significantly higher patient satisfaction (APS-POQ-R-TR score 2.91 vs. 4.42; P < 0.001) and consistently lower pain scores across all time points (P < 0.001). The EOIB group had lower nausea/vomiting scores (P < 0.001), fewer patients requiring antiemetics (16.7% vs. 40%; P = 0.045), longer time to first morphine request (57.5 vs. 25 min; P < 0.001), and lower remifentanil use (850 vs. 1050 μg; P < 0.001).
The preoperative EOIB, as a part of multimodal analgesia, provides effective analgesia for acute pain in patients undergoing LSG.
腹腔镜袖状胃切除术(LSG)会导致显著的术后疼痛,因此需要有效的多模式镇痛策略。本研究评估了在此背景下腹外斜肌肋间阻滞(EOIB)的疗效。
这项前瞻性、随机、对照、单盲研究于2023年4月至12月进行,纳入了60例行LSG的患者。患者被分为EOIB组(每侧30 ml 0.25%布比卡因)和对照组(不进行阻滞)。主要结局是术后24小时内静脉注射吗啡毫克当量(MME)的累计消耗量。次要结局包括术后12小时MME消耗量、疼痛评分、术中瑞芬太尼使用量、补救镇痛需求、首次镇痛请求时间、恶心/呕吐评分、止吐药使用情况以及美国疼痛协会患者结局问卷修订版土耳其语版本(APS-POQ-R-TR)评分。
术后12小时(14.4 vs. 5.8 mg;P < 0.001)和24小时(25.9 vs. 10.6 mg;P < 0.001)时,对照组的阿片类药物消耗量中位数显著高于EOIB组。补救镇痛的需求无显著差异(43.3% vs. 23.3%;P = 0.1)。EOIB组患者满意度显著更高(APS-POQ-R-TR评分2.91 vs. 4.42;P < 0.001),并且在所有时间点的疼痛评分始终更低(P < 0.001)。EOIB组恶心/呕吐评分更低(P < 0.001),需要使用止吐药的患者更少(16.7% vs. 40%;P = 0.045),首次请求使用吗啡的时间更长(57.5 vs. 25分钟;P < 0.001),瑞芬太尼使用量更低(850 vs. 1050 μg;P < 0.001)。
术前EOIB作为多模式镇痛的一部分,为行LSG的患者的急性疼痛提供了有效的镇痛效果。