Ye Yurong, Hu Zizhong, Su Na, Shen Yeyu, Yuan Songtao
Department of Ophthalmology, BenQ Medical Center Affiliated to Nanjing Medical University, Nanjing, China.
Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Ophthalmol (Lausanne). 2025 Jan 6;4:1540410. doi: 10.3389/fopht.2024.1540410. eCollection 2024.
The pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius ratio ( ) and choroidal blood flow.
This cross-sectional study included 202 eyes from myopic children, categorized into 141 eyes with mild myopia, 47 eyes with moderate myopia, and 14 eyes with high myopia. Optical coherence tomography angiography (OCTA) was used to measure choroidal blood flow perfusion within a 6 mm × 6 mm area of the macular region, divided into nine subareas based on ETDRS partitioning: macular fovea, nasal side 1, superior 1, temporal side 1, inferior 1, nasal side 2, superior 2, temporal side 2, and inferior 2. Data on corneal curvature and ocular axial length were collected to calculate the , with equivalent spherical lens power, gender, and age gathered for group comparisons, and the correlation between AL/CR and choroidal blood flow perfusion volume was analyzed.
was significantly negatively correlated with choroidal blood flow perfusion ( ). Linear regression and mediation analyses indicated that for each unit increase in choroidal blood perfusion volume in nasal region 1, decreased by an average of 0.421 units. This relationship is mediated by several factors, with axial length serving as a key mediator.
correlates with choroidal blood flow perfusion, indicating a link between refractive biological parameters and ocular blood circulation. Myopia is an ischemic eye condition that warrants attention to fundus microcirculation changes in myopic children.
早发性近视的病理生理机制尚不清楚；在本研究中，我们通过检查眼轴长度与角膜曲率半径比（ ）和脉络膜血流之间的相互关系来研究其发病机制。
这项横断面研究纳入了202只近视儿童的眼睛，分为141只轻度近视眼睛、47只中度近视眼睛和14只高度近视眼睛。使用光学相干断层扫描血管造影（OCTA）测量黄斑区6 mm×6 mm区域内的脉络膜血流灌注，根据早期糖尿病性视网膜病变研究（ETDRS）分区将其分为九个子区域：黄斑中心凹、鼻侧1、上方1、颞侧1、下方1、鼻侧2、上方2、颞侧2和下方2。收集角膜曲率和眼轴长度数据以计算 ，收集等效球镜度、性别和年龄进行组间比较，并分析眼轴长度与角膜曲率半径比（AL/CR）和脉络膜血流灌注量之间的相关性。
与脉络膜血流灌注显著负相关（ ）。线性回归和中介分析表明，鼻侧区域1脉络膜血流灌注量每增加一个单位， 平均降低0.421个单位。这种关系由几个因素介导，眼轴长度是关键中介因素。
与脉络膜血流灌注相关，表明屈光生物学参数与眼部血液循环之间存在联系。近视是一种缺血性眼病，值得关注近视儿童眼底微循环的变化。
