Xu Yun Rong, Tang Dai Yuan, Xiao Zhen Ping, Huang Zai Tian, Zhang Heng Rui, Tang Zi Wen, He Fei
Qujing Affiliated Hospital of Kunming Medical University, Qujing, China.
The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Front Bioeng Biotechnol. 2025 Jan 6;12:1495810. doi: 10.3389/fbioe.2024.1495810. eCollection 2024.
Researchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have garnered increasing attention. , the orientation and diameter of scaffold materials can exert different effects on osteogenesis and vascularisation. However, more comprehensive investigations, including studies, are required to confirm the results observed . Accordingly, in the present study, fibre scaffolds with various orientations and diameters were prepared by electrospinning with polylactic acid. The effects of the micromorphological characteristics of these scaffolds with different orientations and diameters on osteogenesis and vascularisation were systematically studied via experiments. The scaffolds with aligned micromorphological features positively affected osteogenesis and vascularisation, which indicated that such characteristics could be considered crucial factors when designing materials for bone repair.
再生医学领域的研究人员一直专注于基于天然骨组织的微观结构对工程骨材料进行仿生设计。此外，这些材料的微观形态特征对血管生成的影响也越来越受到关注。支架材料的取向和直径可对成骨作用和血管形成产生不同影响。然而，需要进行更全面的研究，包括 研究，以证实所观察到的结果。因此，在本研究中，通过用聚乳酸进行静电纺丝制备了具有不同取向和直径的纤维支架。通过 实验系统地研究了这些具有不同取向和直径的支架的微观形态特征对成骨作用和血管形成的影响。具有排列微观形态特征的支架对成骨作用和血管形成有积极影响，这表明在设计骨修复材料时，这些特征可被视为关键因素。
