Wang Ziyang, Xu Wen, Liu Dan, Li Xiuqi, Liu Shupeng, Wu Xiaofei, Wang Hongyun
Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang, People's Republic of China.
Drug Des Devel Ther. 2025 Jan 16;19:267-280. doi: 10.2147/DDDT.S497515. eCollection 2025.
Food-Drug Interaction (FDI) refers to the phenomenon where food affects the pharmacokinetic or pharmacodynamic characteristics of a drug, significantly altering the drug's absorption rate or absorption extent. These Interactions are considered as a primary determinant in influencing the bioavailability of orally administered drugs within the gastrointestinal tract. The impact of food on drug absorption is complex and multifaceted, potentially involving alterations in gastrointestinal physiology, increases in splanchnic blood flow rates, and shifts in the gut microbiota's composition. Up to now, extensive research has focused on the interactions between food composition (such as proteins, fats, and vitamins) and drug absorption. In contrast, the impact of food physical properties (such as viscosity, volume, and pH) has received less attention in drug development. This article reviewed the impact of food properties on oral drug absorption based on a comprehensive literature search, focusing on the influence of food volume and food viscosity. From the perspective of pharmacokinetics, we examined interaction trends between food properties and drugs across different classification based on the Biopharmaceutics Classification System (BCS). In addition, we introduced the practical application of physiologically based pharmacokinetic (PBPK) modeling in predicting oral drug absorption under the influence of food Properties.
食物-药物相互作用（FDI）是指食物影响药物的药代动力学或药效学特性，显著改变药物的吸收速率或吸收程度的现象。这些相互作用被认为是影响胃肠道内口服药物生物利用度的主要决定因素。食物对药物吸收的影响是复杂且多方面的，可能涉及胃肠道生理的改变、内脏血流量的增加以及肠道微生物群组成的变化。到目前为止，广泛的研究集中在食物成分（如蛋白质、脂肪和维生素）与药物吸收之间的相互作用。相比之下，食物物理性质（如粘度、体积和pH值）对药物研发的影响较少受到关注。本文基于全面的文献检索，综述了食物性质对口服药物吸收的影响，重点关注食物体积和食物粘度的影响。从药代动力学的角度，我们根据生物药剂学分类系统（BCS），研究了不同分类下食物性质与药物之间的相互作用趋势。此外，我们介绍了基于生理的药代动力学（PBPK）模型在预测食物性质影响下口服药物吸收方面的实际应用。
