曲唑酮是一种非三环类抗抑郁药，是腺苷脱氨酶的抑制剂。
Trazodone, a nontricyclic antidepressant, is an inhibitor of adenosine deaminase.
作者信息
Sheid B
出版信息
Res Commun Chem Pathol Pharmacol. 1985 Jan;47(1):149-52.
PMID:3983468
Abstract
Trazodone, a nontricyclic antidepressant drug, is a noncompetitive inhibitor of adenosine deaminase. The specific activity of adenosine deaminase in rat brain cortex homogenate is 140 +/- 15 (SEM) nm/min/gm tissue, while the apparent Km of adenosine is 77 microM. The apparent Ki of trazodone for the brain cortex enzyme is 1 X 10(-4)M, and 6 X 10(-5)M for purified calf intestine mucosal enzyme.
摘要
曲唑酮是一种非三环类抗抑郁药，是腺苷脱氨酶的非竞争性抑制剂。大鼠脑皮质匀浆中腺苷脱氨酶的比活性为140±15（标准误）纳米/分钟/克组织，而腺苷的表观米氏常数为77微摩尔。曲唑酮对脑皮质酶的表观抑制常数为1×10⁻⁴摩尔，对纯化的小牛肠黏膜酶的表观抑制常数为6×10⁻⁵摩尔。
Zotero 插件