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卵巢小细胞癌,高钙血症型,导致急性肾损伤。

Small cell carcinoma of the ovary, hypercalcaemic type causing an acute kidney injury.

作者信息

Baker-Rand Holly, Shawky Mohamed, Agrawal Surabhi, Morrison Jo

机构信息

Division of Cancer Sciences, The University of Manchester, Manchester, UK.

Gynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UK.

出版信息

BMJ Case Rep. 2025 Jan 20;18(1):e262687. doi: 10.1136/bcr-2024-262687.

Abstract

SummaryWe report a case of small cell carcinoma of the ovary, hypercalcaemic type, a rare and aggressive form of ovarian cancer, causing an acute kidney injury. A woman in her mid-30s presented with a large pelvic mass and abdominal distention, this was associated with rapidly deteriorating renal function, which did not improve with standardised kidney injury treatment. There was a high suspicion of ovarian cancer. She deteriorated and underwent emergency cytoreductive surgery, followed by systemic chemotherapy. Her presentation, acute kidney injury and electrolyte disturbance preoperatively and postoperatively suggest this was caused by her cancer. Renal dysfunction, due to paraneoplastic syndromes, is a rare oncological emergency seen with solid tumours. Awareness of the condition can lead to early recognition and timely management.

摘要

摘要

我们报告一例卵巢小细胞癌(高钙血症型),这是一种罕见且侵袭性强的卵巢癌形式,可导致急性肾损伤。一名35岁左右的女性因盆腔巨大肿块和腹胀就诊,同时伴有肾功能迅速恶化,标准化肾损伤治疗后未见改善。高度怀疑为卵巢癌。她病情恶化,接受了急诊细胞减灭术,随后进行全身化疗。她术前和术后出现的急性肾损伤及电解质紊乱提示这是由癌症引起的。由于副肿瘤综合征导致的肾功能障碍是实体瘤中罕见的肿瘤急症。对该病症的认识有助于早期识别和及时处理。

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本文引用的文献

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JAMA. 2022 Oct 25;328(16):1624-1636. doi: 10.1001/jama.2022.18331.
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Perioperative Acute Kidney Injury.围手术期急性肾损伤。
Anesthesiology. 2020 Jan;132(1):180-204. doi: 10.1097/ALN.0000000000002968.

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