McCaig Colin D
Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
Rev Physiol Biochem Pharmacol. 2025;187:89-101. doi: 10.1007/978-3-031-68827-0_9.
Cell membranes contain multiple charged lipids that bind proteins dynamically and their spatial organization on the inner/outer membrane leaflet, or in spatially localized areas has considerable biological importance. Myristoylated alanine-rich C kinase substrate (MARCKS) proteins and their roles as electrostatic switches are one example covered. Cell surface charge needs to be monitored and regulated continually and the roles of lipid flippases and scramblases and their electrical regulation also are considered.
细胞膜包含多种带电荷的脂质，这些脂质能动态结合蛋白质，并且它们在内膜/外膜小叶或空间定位区域的空间组织具有相当重要的生物学意义。肉豆蔻酰化富含丙氨酸的蛋白激酶C底物（MARCKS）蛋白及其作为静电开关的作用就是其中一个例子。细胞表面电荷需要持续监测和调节，脂质翻转酶和翻转酶的作用及其电调节也在考虑之中。
