van Dam-Mieras M C, Muller A D, van Deijk W A, Hemker H C
Thromb Res. 1985 Jan 1;37(1):9-19. doi: 10.1016/0049-3848(85)90028-3.
The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin in the culture medium is shown to decrease the vitamin K dependent clotting factor activity in the supernatant after in vitro culture of rat spleen macrophages and human peripheral blood monocytes.
已对大鼠脾脏巨噬细胞和人外周血单核细胞凝血因子的分泌进行了研究。结果表明，所测得的凝血因子量严重取决于所用检测系统的特性。结果显示，在大鼠脾脏巨噬细胞和人外周血单核细胞体外培养后，培养基中存在华法林、水杨酸或凝血酶会降低上清液中维生素K依赖性凝血因子的活性。
