Chiba M, Fujimoto N, Kikuchi M
Toxicol Lett. 1985 Feb-Mar;24(2-3):235-41. doi: 10.1016/0378-4274(85)90063-3.
The protective effect of selenium (Se) on the inhibition of erythrocyte 5-aminolevulinate dehydratase (ALAD) activity by tin (Sn) was examined in mice. When mice were intraperitoneally (i.p.) administered 10 mumol/kg of stannous chloride, the activity of erythrocyte ALAD decreased to 35% of control. When more than an equimolar dose of sodium selenite was injected i.p. simultaneously with Sn, the ALAD activity was completely protected. Mortalities and weight gains of mice treated with Se were also reduced when Sn was administered simultaneously.
在小鼠中研究了硒（Se）对锡（Sn）抑制红细胞5-氨基酮戊酸脱水酶（ALAD）活性的保护作用。当给小鼠腹腔注射10 μmol/kg氯化亚锡时，红细胞ALAD活性降至对照的35%。当与Sn同时腹腔注射等摩尔以上剂量的亚硒酸钠时，ALAD活性得到完全保护。同时给予Sn时，用Se处理的小鼠的死亡率和体重增加也降低了。
