给予锡或铅的家兔血液中5-氨基乙酰丙酸脱水酶活性

5-aminolevulinate dehydratase activity in blood of rabbits given tin or lead.

作者信息

Chiba M, Kikuchi M

出版信息

Br J Ind Med. 1979 Nov;36(4):323-5. doi: 10.1136/oem.36.4.323.

DOI:10.1136/oem.36.4.323

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1008610/

Abstract

The activity of 5-aminolevulinate dehydratase (ALAD) in rabbit blood is significantly inhibited by tin. Intravenous administration of tin (0.48 or 4.8 mumol/kg body weight) causes a decrease in the activity of the enzyme by 60% or 94% respectively. The effects of tin and lead on ALAD differ: inhibition by tin is not affected by pre-incubation at 50-60 degrees C, whereas the inhibitory effect of lead is increased by the same pretreatment. The optimum pH for rabbit blood ALAD is 6.8 in control rabbits. This optimum shifts to pH 5.8-6.0 in the blood of tin-treated rabbits, with or without pre-incubation at 60 degrees C for 5 min, while a similar shift is prevented by the same pre-incubation after lead treatment. Recovery to normal activity is faster after tin than after lead treatment.

摘要

锡能显著抑制兔血中5-氨基乙酰丙酸脱水酶（ALAD）的活性。静脉注射锡（0.48或4.8 μmol/kg体重）分别导致该酶活性降低60%或94%。锡和铅对ALAD的影响不同：锡的抑制作用不受50 - 60℃预孵育的影响，而铅的抑制作用通过相同的预处理会增强。对照兔中兔血ALAD的最适pH值为6.8。在经锡处理的兔血中，无论是否在60℃预孵育5分钟，该最适pH值都会移至5.8 - 6.0，而铅处理后进行相同的预孵育可防止这种类似的偏移。锡处理后恢复到正常活性比铅处理后更快。

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本文引用的文献

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Early signs of lead-exposure. A comparative study of laboratory tests.铅暴露的早期迹象。实验室检测的比较研究。

Br J Ind Med. 1967 Jul;24(3):203-12. doi: 10.1136/oem.24.3.203.

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Erythrocyte delta-aminolevulinic acid dehydratase in new lead exposure: a longitudinal study.新铅暴露情况下红细胞δ-氨基乙酰丙酸脱水酶：一项纵向研究

Arch Environ Health. 1972 Aug;25(2):109-13. doi: 10.1080/00039896.1972.10666145.

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