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1
5-aminolevulinate dehydratase activity in blood of rabbits given tin or lead.给予锡或铅的家兔血液中5-氨基乙酰丙酸脱水酶活性
Br J Ind Med. 1979 Nov;36(4):323-5. doi: 10.1136/oem.36.4.323.
2
The in vitro effects of zinc and manganese on delta-aminolevulinic acid dehydratase activity inhibited by lead or tin.锌和锰对铅或锡抑制的δ-氨基乙酰丙酸脱水酶活性的体外作用
Toxicol Appl Pharmacol. 1984 May;73(3):388-94. doi: 10.1016/0041-008x(84)90090-5.
3
Protective effect of selenium on the inhibition of erythrocyte 5-aminolevulinate dehydratase activity by tin.硒对锡抑制红细胞5-氨基酮戊酸脱水酶活性的保护作用。
Toxicol Lett. 1985 Feb-Mar;24(2-3):235-41. doi: 10.1016/0378-4274(85)90063-3.
4
Effect of tin compounds on activity of 5-aminolevulinate dehydratase in blood.锡化合物对血液中5-氨基乙酰丙酸脱水酶活性的影响。
Biochem Biophys Res Commun. 1978 Jun 29;82(4):1057-61. doi: 10.1016/0006-291x(78)90294-2.
5
The in vivo effects of manganese and zinc on delta-aminolevulinic acid dehydratase activity inhibited by lead.锰和锌对铅抑制的δ-氨基乙酰丙酸脱水酶活性的体内影响。
Toxicol Lett. 1984 Feb;20(2):143-7. doi: 10.1016/0378-4274(84)90139-5.
6
Antagonistic effect in vivo of zinc on inhibition of delta-aminolevulinic acid dehydratase by lead.锌在体内对铅抑制δ-氨基乙酰丙酸脱水酶的拮抗作用。
Arch Environ Health. 1976 Jul-Aug;31(4):215-20. doi: 10.1080/00039896.1976.10667222.
7
Effect of tin on porphyrin biosynthesis.锡对卟啉生物合成的影响。
Arch Toxicol. 1980 Sep;45(3):189-95. doi: 10.1007/BF02418997.
8
Aminolevulinic acid dehydratase activity in the blood of rats exposed to tin and zinc.暴露于锡和锌的大鼠血液中的氨基乙酰丙酸脱水酶活性。
Ecotoxicol Environ Saf. 1985 Feb;9(1):40-6. doi: 10.1016/0147-6513(85)90032-6.
9
Metal constitution of metallothionein influences inhibition of delta-aminolaevulinic acid dehydratase (porphobilinogen synthase) by lead.金属硫蛋白的金属组成影响铅对δ-氨基乙酰丙酸脱水酶（胆色素原合酶）的抑制作用。
Biochem J. 1987 Jul 15;245(2):339-45. doi: 10.1042/bj2450339.
10
If there is an effect of lead exposure on malaria, then the activity of delta-aminolevulinate dehydratase (ALAD) may play a role, as ALAD is imported by the parasite from the host.如果铅暴露对疟疾有影响，那么δ-氨基乙酰丙酸脱水酶（ALAD）的活性可能起作用，因为该酶是寄生虫从宿主中摄取的。
Int J Hyg Environ Health. 2009 Jul;212(4):445-6, author reply 447-8. doi: 10.1016/j.ijheh.2008.10.003. Epub 2008 Dec 4.

引用本文的文献

1
The effect of testosterone administration on lead induced zincprotoporphyrin in blood concentration in castrated male rabbits.睾酮给药对去势雄性兔血液中铅诱导的锌原卟啉浓度的影响。
Arch Toxicol. 1981 Nov;49(1):65-71. doi: 10.1007/BF00352073.
2
Mechanisms of ALA-D inhibition by lead and of its restoration by zinc and dithiothreitol.铅对δ-氨基-γ-酮戊酸脱水酶（ALA-D）的抑制机制以及锌和二硫苏糖醇对其的恢复机制。
Br J Ind Med. 1983 Feb;40(1):61-6. doi: 10.1136/oem.40.1.61.

本文引用的文献

1
Early signs of lead-exposure. A comparative study of laboratory tests.铅暴露的早期迹象。实验室检测的比较研究。
Br J Ind Med. 1967 Jul;24(3):203-12. doi: 10.1136/oem.24.3.203.
2
Erythrocyte delta-aminolevulinic acid dehydratase in new lead exposure: a longitudinal study.新铅暴露情况下红细胞δ-氨基乙酰丙酸脱水酶：一项纵向研究
Arch Environ Health. 1972 Aug;25(2):109-13. doi: 10.1080/00039896.1972.10666145.

给予锡或铅的家兔血液中5-氨基乙酰丙酸脱水酶活性

5-aminolevulinate dehydratase activity in blood of rabbits given tin or lead.

作者信息

Chiba M, Kikuchi M

出版信息

Br J Ind Med. 1979 Nov;36(4):323-5. doi: 10.1136/oem.36.4.323.

DOI:10.1136/oem.36.4.323
PMID:508644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1008610/
Abstract

The activity of 5-aminolevulinate dehydratase (ALAD) in rabbit blood is significantly inhibited by tin. Intravenous administration of tin (0.48 or 4.8 mumol/kg body weight) causes a decrease in the activity of the enzyme by 60% or 94% respectively. The effects of tin and lead on ALAD differ: inhibition by tin is not affected by pre-incubation at 50-60 degrees C, whereas the inhibitory effect of lead is increased by the same pretreatment. The optimum pH for rabbit blood ALAD is 6.8 in control rabbits. This optimum shifts to pH 5.8-6.0 in the blood of tin-treated rabbits, with or without pre-incubation at 60 degrees C for 5 min, while a similar shift is prevented by the same pre-incubation after lead treatment. Recovery to normal activity is faster after tin than after lead treatment.

摘要

锡能显著抑制兔血中5-氨基乙酰丙酸脱水酶（ALAD）的活性。静脉注射锡（0.48或4.8 μmol/kg体重）分别导致该酶活性降低60%或94%。锡和铅对ALAD的影响不同：锡的抑制作用不受50 - 60℃预孵育的影响，而铅的抑制作用通过相同的预处理会增强。对照兔中兔血ALAD的最适pH值为6.8。在经锡处理的兔血中，无论是否在60℃预孵育5分钟，该最适pH值都会移至5.8 - 6.0，而铅处理后进行相同的预孵育可防止这种类似的偏移。锡处理后恢复到正常活性比铅处理后更快。