Mauritz Matthias, Kliushnikova Dariia, Otto Ferdinand, Harrer Andrea, Moser Tobias, Radlberger Richard Friedrich, Kleindienst Waltraud, Trinka Eugen, Wipfler Peter
Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria.
Department of Dermatology and Allergology, Paracelsus Medical University, Salzburg, Austria.
Front Immunol. 2025 Jan 7;15:1517719. doi: 10.3389/fimmu.2024.1517719. eCollection 2024.
The reversible splenial lesion syndrome is frequently associated with systemic and central nervous system infections. Whether an infection associated with the occurrence of the reversible splenial lesion syndrome could play a role in the later development of multiple sclerosis is unknown.
Case Report.
A 27-year-old woman developed an infection-related reversible splenial lesion syndrome. Diagnostic findings did not establish a specific type of infection, but revealed evidence for a potential disposition towards autoimmunity. 32 months after the initial presentation, new clinical and radiological manifestations developed that led to a diagnosis of multiple sclerosis.
In susceptible individuals, infectious disease processes involving the central nervous system, such as described in this case, might be a factor in the pathogenesis of multiple sclerosis. More research on the prodromal stage of multiple sclerosis is needed to better understand the relationship between infections and autoimmunity.
可逆性胼胝体病变综合征常与全身及中枢神经系统感染相关。与可逆性胼胝体病变综合征发生相关的感染是否会在多发性硬化症的后期发展中起作用尚不清楚。
病例报告。
一名27岁女性患上了与感染相关的可逆性胼胝体病变综合征。诊断结果未明确具体的感染类型，但显示出潜在的自身免疫倾向证据。首次出现症状32个月后，出现了新的临床和影像学表现，最终诊断为多发性硬化症。
在易感个体中，如本病例所述的涉及中枢神经系统的感染过程可能是多发性硬化症发病机制中的一个因素。需要对多发性硬化症的前驱期进行更多研究，以更好地理解感染与自身免疫之间的关系。
