Liu Cai-Yue, Li Zheng, Cheng Fan-E, Nan Yi, Li Wei-Qiang
Ningxia Medical University, Ningxia of Traditional Chinese Medicine, Yinchuan, China.
Key Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, China.
Front Pharmacol. 2025 Jan 7;15:1498707. doi: 10.3389/fphar.2024.1498707. eCollection 2024.
Radix Codonopsis (Dangshen), derived from the dried root of plants in the Campanulaceae family, is a widely used Chinese herbal medicine. It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishing the blood. Codonopsis extract is frequently incorporated into health products such as tablets and capsules, making it accessible for daily health maintenance. Additionally, it is commonly used in dietary applications like soups, teas, and porridges to nourish qi, enrich blood, and promote overall vitality. In recent years, increasing attention has been given to the anti-cancer potential of Radix Codonopsis. Studies have identified key active components such as luteolin, stigmasterol, polyacetylenes, lobetyolin, and glycitein, which exhibit anti-tumor properties through mechanisms like inhibiting cancer cell growth and proliferation, suppressing epithelial-mesenchymal transition (EMT), and inducing apoptosis. This review highlights the research progress on Radix Codonopsis, including its active constituents, anti-cancer mechanisms, and its role in the convergence of medicine and food in modern life. By doing so, it aims to provide valuable insights and references for future scientific studies and clinical applications of Radix Codonopsis.
党参来源于桔梗科植物的干燥根，是一种广泛应用的中药材。它以其药理作用而闻名，包括补中益气、健脾益肺、增强免疫力和养血。党参提取物经常被添加到片剂和胶囊等保健品中，便于日常保健。此外，它还常用于汤、茶和粥等饮食应用中，以补气养血，促进整体活力。近年来，党参的抗癌潜力受到越来越多的关注。研究已经确定了关键活性成分，如木犀草素、豆甾醇、聚乙炔、党参炔苷和黄豆黄素，它们通过抑制癌细胞生长和增殖、抑制上皮-间质转化（EMT）和诱导凋亡等机制表现出抗肿瘤特性。本综述重点介绍了党参的研究进展，包括其活性成分、抗癌机制以及在现代生活中作为药食同源的作用。通过这样做，旨在为党参未来的科学研究和临床应用提供有价值的见解和参考。
