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[高温对人类淋巴细胞染色体的影响]

[Effect of elevated temperatures on human lymphocyte chromosomes].

作者信息

Govorun R D, Ovodkov Iu V, Fomenkova T E

出版信息

Tsitologiia. 1985 Jan;27(1):83-7.

PMID:3984031
Abstract

The influence of elevated temperatures (38-41 degrees C) on chromosomes of human lymphocytes on different phases of the cell cycle was studied. A high thermosensitivity of chromosomes was demonstrated during (S + G2)-phases of the cell cycle. There was a significant increase in the number of aberrant cells at t greater than 38.5%. The main types of chromosome aberrations were chromatid and chromosome deletions. Cells with 3-5 aberrations and induction of chromosome aberrations due to breaks in the centromere region were noticed at high temperatures (40-41 degrees).

摘要

研究了高温(38 - 41摄氏度)对处于细胞周期不同阶段的人淋巴细胞染色体的影响。在细胞周期的(S + G2)期,染色体表现出高度的热敏感性。当温度高于38.5%时,异常细胞数量显著增加。染色体畸变的主要类型是染色单体和染色体缺失。在高温(40 - 41摄氏度)下,观察到具有3 - 5个畸变的细胞以及由于着丝粒区域断裂导致的染色体畸变。

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