Yan Ming, Hu Shi-Yu, Tan Hao-Jie, Dai Rui, Wang Haibo, Peng Xu, Wang Zhi-Guo, Xu Jia-Zhuang, Li Zhong-Ming
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China.
Adv Healthc Mater. 2025 Mar;14(7):e2404447. doi: 10.1002/adhm.202404447. Epub 2025 Jan 22.
The hydrogel adhesives with strong tissue adhesion and biological characteristics are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion. The double cross-linked network is achieved through the cooperation between polyacrylic acid grafted with N-hydroxy succinimide crosslinked by tannic acid and cohesion-enhanced ion crosslinking of sodium alginate and Ca. Such a unique structure endows the resultant hydrogel adhesive with excellent tissue adhesion strength and mechanical strength. The hydrogel adhesive is capable of sealing various organs in vitro, and exhibits satisfactory on-demand removability, antibacterial, and antioxidant properties. As a proof of concept, the hydrogel adhesive not only effectively halts non-compressible hemorrhages of beating heart and femoral artery injury models in rats, but also accelerates the healing of infected wound by inhibiting bacteria and reducing inflammation. Overall, this advanced hydrogel adhesive is promising as an emergency rescue adhesive that enables robust tissue closure, timely controlling bleeding, and promoting damaged tissue healing.
具有强组织粘附性和生物学特性的水凝胶粘合剂对于伤口封闭和组织修复至关重要。然而，组织粘附性与机械强度之间的负相关关系给它们的实际应用带来了挑战。在此，我们开发了一种仿生内聚增强策略，以制备同时具有增强的机械强度和组织粘附性的水凝胶粘合剂。通过单宁酸交联的接枝N-羟基琥珀酰亚胺的聚丙烯酸与海藻酸钠和钙的内聚增强离子交联之间的协同作用，实现了双交联网络。这种独特的结构赋予所得水凝胶粘合剂优异的组织粘附强度和机械强度。该水凝胶粘合剂能够在体外封闭各种器官，并表现出令人满意的按需可移除性、抗菌和抗氧化性能。作为概念验证，该水凝胶粘合剂不仅能有效止住大鼠心脏跳动和股动脉损伤模型的不可压缩出血，还能通过抑制细菌和减轻炎症来加速感染伤口的愈合。总体而言，这种先进的水凝胶粘合剂有望成为一种紧急救援粘合剂，能够实现强大的组织闭合、及时控制出血并促进受损组织愈合。
