Sun Tianze, Wang Junlin, Liu Xin, Huang Huagui, Wang Jinzuo, Suo Moran, Zhang Jing, Li Zhonghai
Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, The People's Republic of China.
Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Liaoning Province, Dalian, The People's Republic of China.
Ann Med. 2025 Dec;57(1):2453089. doi: 10.1080/07853890.2025.2453089. Epub 2025 Jan 22.
The incidence rate of intervertebral disc degeneration (IVDD) is increasing year by year, which brings great harm to our health. The change of biomechanical factors is an important reason for IVDD. Therefore, more and more studies use finite element (FE) models to analyze the biomechanics of spine.
In this review, literatures which reported the FE model of intervertebral disc (IVD) were reviewed. We summarized the types and constructional methods of the FE models and analyzed the applications of some representative FE models.
The most widely used model was the nonlinear model which considers the behavior of porous elastic materials. As more advanced methods, More and more models which involve penetration parameters were used to simulate the biological behavior and biomechanical properties of IVD.
Personalized modeling should be carried out in order to better provide accurate basis for the diagnosis and treatment of the disease. In addition, microstructure, cell behavior and complex load should be considered in the process of model construction to build a more realistic model.
椎间盘退变（IVDD）的发病率逐年上升，给我们的健康带来极大危害。生物力学因素的改变是IVDD的一个重要原因。因此，越来越多的研究使用有限元（FE）模型来分析脊柱的生物力学。
在本综述中，对报道椎间盘（IVD）有限元模型的文献进行了回顾。我们总结了有限元模型的类型和构建方法，并分析了一些具有代表性的有限元模型的应用。
使用最广泛的模型是非线性模型，该模型考虑了多孔弹性材料的行为。作为更先进的方法，越来越多涉及渗透参数的模型被用于模拟IVD的生物学行为和生物力学特性。
为了更好地为疾病的诊断和治疗提供准确依据，应进行个性化建模。此外，在模型构建过程中应考虑微观结构、细胞行为和复杂载荷，以构建更逼真的模型。
