Lopez-Llera M, Niz Ramos J, Espinosa M L
Int J Gynaecol Obstet. 1978;17(1):63-7. doi: 10.1002/j.1879-3479.1979.tb00117.x.
The potential differences in hematologic profiles of blood samples drawn simultaneously from the right utero-ovarian vein and from the upper extremity were investigated in four patients with uncomplicated molar pregnancy in stable obstetric conditions. The patients had undergone no previous chemotherapy and were scheduled for total abdominal hysterectomies. The dominant abnormalities in uterine venous blood were prolongation of thrombin time; shortening of activated partial thromboplastin time; positive protamine sulfate test; and increase in coagulation factors II and VII, with a tendency to low values in factor V. Peripheral samples gave almost parallel results in all altered and normal tests, except in one case with very striking differences in factors II, V, VII and X. Several local and systemic influences are discussed. It is concluded that molar pregnancy seems to have important systemic mechanisms affecting the stability of the blood coagulation homeostasis, which act in addition to those at a local level.
对4例产科情况稳定、未并发葡萄胎妊娠的患者，研究了同时从右侧子宫卵巢静脉和上肢采集的血样在血液学指标上的潜在差异。这些患者既往未接受过化疗，计划行全腹子宫切除术。子宫静脉血的主要异常表现为凝血酶时间延长；活化部分凝血活酶时间缩短；硫酸鱼精蛋白试验阳性；凝血因子II和VII增加，而因子V有降低趋势。除1例患者的因子II、V、VII和X有非常显著差异外，外周血样本在所有异常和正常检测中结果几乎平行。讨论了几种局部和全身影响因素。得出的结论是，葡萄胎妊娠似乎有重要的全身机制影响凝血内稳态的稳定性，这些机制除了在局部起作用外还会发挥作用。
