Hoang Uy, Agrawal Utkarsh, Ordóñez-Mena José Manuel, Marcum Zachary, Radin Jennifer, Araujo Andre, Panozzo Catherine A, Balogh Orsolya, Desai Mihir, Eltayeb Ahreej, Lu Tianyi, Nicodemo Catia, Gu Xinchun, Goudie Rosalind, Fan Xuejuan, Button Elizabeth, Smylie Jessica, Joy Mark, Jamie Gavin, Elson William, Byford Rachel, Madia Joan, Anand Sneha, Ferreira Filipa, Petrou Stavros, Martin David, de Lusignan Simon
Clinical Informatics and Health Outcomes Research Group, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Aetion, Inc, New York, NY, United States.
JMIR Res Protoc. 2025 Jan 22;14:e60669. doi: 10.2196/60669.
There are gaps in our understanding of the clinical characteristics and disease burden of the respiratory syncytial virus (RSV) among community-dwelling adults. This is in part due to a lack of routine testing at the point of care. More data would enhance our assessment of the need for an RSV vaccination program for adults in the United Kingdom.
This study aimed to implement point-of-care-testing (POCT) in primary care to describe the incidence, clinical presentation, risk factors, and economic burden of RSV among adults presenting with acute respiratory infection.
We are recruiting up to 3600 patients from at least 21 practices across England to participate in the Royal College of General Practitioners Research Surveillance Centre. Practices are selected if they undertake reference virology sampling for the Royal College of General Practitioners Research Surveillance Centre and had previous experience with respiratory illness studies. Any adult, ≥40 years old, presenting with acute respiratory infection with onset ≤10 days, but without RSV within the past 28 days, will be eligible to participate. We will estimate the incidence proportion of RSV, describe the clinical features, and risk factors of patients with RSV infection, and measure the economic burden of RSV infection.
A total of 25 practices across different English health administrative regions expressed interest and were recruited to participate. We have created and tested an educational program to deploy POCT for RSV in primary care. In addition to using the POCT device, we provide suggestions about how to integrate POCT into primary care workflow and templates for high-quality data recording of diagnosis, symptoms, and signs. In the 2023-2024 winter RSV detection in the sentinel network grew between October and late November. According to data from the UK Health Security Agency, the peak RSV swab positivity was in International Standards Organization week 48, 2023. Data collection remains ongoing, and results from the subset of practices participating in this study are not yet available.
This study will provide data on the RSV incidence in the community as well as rapid information to inform sentinel surveillance and vaccination programs. This information could potentially improve clinical decision-making.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/60669.
我们对社区居住成年人中呼吸道合胞病毒（RSV）的临床特征和疾病负担的了解存在差距。部分原因是缺乏即时护理检测。更多数据将有助于我们评估英国针对成年人的RSV疫苗接种计划的必要性。
本研究旨在在初级保健中实施即时检测（POCT），以描述急性呼吸道感染成人中RSV的发病率、临床表现、危险因素和经济负担。
我们正在从英格兰至少21家医疗机构招募多达3600名患者，参与皇家全科医师学院研究监测中心的研究。如果这些医疗机构为皇家全科医师学院研究监测中心进行参考病毒学采样且有呼吸道疾病研究经验，则会被选中。任何年龄≥40岁、急性呼吸道感染发病≤10天且过去28天内无RSV感染的成年人都有资格参与。我们将估计RSV的发病率，描述RSV感染患者的临床特征和危险因素，并衡量RSV感染的经济负担。
英格兰不同卫生行政区的25家医疗机构表示有兴趣并被招募参与。我们创建并测试了一个教育项目，以便在初级保健中部署RSV的POCT。除了使用POCT设备外，我们还提供有关如何将POCT整合到初级保健工作流程中的建议，以及用于高质量记录诊断、症状和体征数据的模板。在2023 - 2024年冬季，哨点网络中的RSV检测在10月至11月下旬有所增加。根据英国卫生安全局的数据，RSV拭子阳性率峰值出现在2023年国际标准化组织第48周。数据收集仍在进行中，参与本研究的部分医疗机构的结果尚未可得。
本研究将提供社区中RSV发病率的数据以及为哨点监测和疫苗接种计划提供快速信息。这些信息可能会改善临床决策。
国际注册报告识别码（IRRID）：DERR1-10.2196/60669
