Ni Minting, Lin Shengyu, Shao Yongheng, Tang Jiao, Li Shuxian, Tan Chen, Gong Zhenli, Li Hongbo, Wang Jintao, Liu Guangliang, Chen Jianing
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China; College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China.
Virology. 2025 Mar;604:110409. doi: 10.1016/j.virol.2025.110409. Epub 2025 Jan 15.
Parainfluenza virus 5 (PIV5) is a member of the Paramyxoviridae family and causes respiratory symptoms in various animal species. Although the virus has been frequently detected among fecal samples, no study has described its infection of the intestine. Recently, diarrhea with low mortality has spread on pig farms in Gansu, China. Next-generation sequencing confirmed the emergence of PIV5 among the samples. The PIV5 strain was then successfully isolated and characterized in vitro. Further animal tests revealed that PIV5 can result in respiratory symptoms and mild diarrhea in piglets. Immunohistochemical staining confirmed PIV5 infection resulted in steatosis and contributed to diarrhea. A retrospective investigation revealed that the number of cases of PIV5 infection has increased since 2020. Overall, our study is the first to present data indicating that PIV5 infection leads to diarrhea. Although it has low pathogenicity, PIV5 may pose a potential threat to pig production in China.
副流感病毒5型（PIV5）是副粘病毒科的成员，可在多种动物物种中引起呼吸道症状。尽管该病毒在粪便样本中经常被检测到，但尚无研究描述其对肠道的感染情况。最近，中国甘肃省的养猪场出现了低死亡率的腹泻疫情。二代测序证实样本中出现了PIV5。随后成功分离出PIV5毒株并在体外进行了鉴定。进一步的动物试验表明，PIV5可导致仔猪出现呼吸道症状和轻度腹泻。免疫组织化学染色证实PIV5感染导致脂肪变性并引发腹泻。一项回顾性调查显示，自2020年以来，PIV5感染病例数有所增加。总体而言，我们的研究首次提供数据表明PIV5感染会导致腹泻。尽管PIV5致病性较低，但可能对中国的养猪业构成潜在威胁。
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