Liu Jiaqi, Ren Tongwei, Wang Xindong, Wang Hao, Chen Guochang, Qin Yifeng, Ouyang Kang, Chen Ying, Huang Weijian, Wei Zuzhang
Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, 530005, China.
Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, 530005, China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, 530005, China; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, 530005, China.
Virology. 2024 Sep;597:110157. doi: 10.1016/j.virol.2024.110157. Epub 2024 Jul 3.
Reports of Parainfluenza virus 5 (PIV5) epidemics have been on a global upward trend, with an expanding host range across various animals. In 2020, we isolated a PIV5 strain from a PRRSV-positive serum sample. This strain was named GX2020. Genetic analysis revealed that GX2020 belongs to group A, represented by the AGS strain isolated from a human in the USA. Comparisons of amino acid identity in the coding regions showed that GX2020 had the highest amino acid identity (99.6%) with the AGS strain. The emergence of PIV5 strains genetically similar to human strains in pigs highlights its zoonotic potential and underscores the need for enhanced PIV5 surveillance in the future.
副流感病毒5型（PIV5）疫情报告呈全球上升趋势，其宿主范围在各种动物中不断扩大。2020年，我们从一份猪繁殖与呼吸综合征病毒（PRRSV）阳性血清样本中分离出一株PIV5毒株。该毒株被命名为GX2020。基因分析表明，GX2020属于A组，由从美国一名人类身上分离出的AGS毒株代表。编码区氨基酸同一性比较显示，GX2020与AGS毒株的氨基酸同一性最高（99.6%）。猪中出现与人类毒株基因相似的PIV5毒株凸显了其人畜共患病潜力，并强调未来需要加强PIV5监测。
