Promotion or inhibition? This is a question in gene editing.
作者信息
Tsai Li-Kuang, Han Renzhi, Yang Dongshan, Chen Y Eugene, Zhang Jifeng, Xu Jie
机构信息
Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Mol Ther. 2025 Feb 5;33(2):444-446. doi: 10.1016/j.ymthe.2025.01.014. Epub 2025 Jan 21.
Abstract
摘要
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本文引用的文献
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Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.使用增强同源定向修复（HDR）的DNA依赖蛋白激酶催化亚基（DNA-PKcs）抑制剂AZD7648进行基因组编辑会导致大规模基因组改变。
Nat Biotechnol. 2024 Nov 27. doi: 10.1038/s41587-024-02488-6.
2
MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits.微 Cas9 提高了大尺寸基因敲入的效率，并降低了不必要的脱靶和靶外插入缺失编辑。
Nat Commun. 2020 Nov 27;11(1):6082. doi: 10.1038/s41467-020-19842-2.
3
Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors.通过Cas9与同源重组因子的结合增强精确基因编辑
Front Genet. 2019 Apr 30;10:365. doi: 10.3389/fgene.2019.00365. eCollection 2019.
4
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing.RAD52 和 dn53BP1 的异位表达可提高 CRISPR-Cas9 基因组编辑过程中的同源定向修复。
Nat Biomed Eng. 2017 Nov;1(11):878-888. doi: 10.1038/s41551-017-0145-2. Epub 2017 Oct 9.
5
Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells.小分子靶向修复途径可提高多能干细胞中精确的基因组编辑效率。
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A Versatile Tool for the Quantification of CRISPR/Cas9-Induced Genome Editing Events in Human Hematopoietic Cell Lines and Hematopoietic Stem/Progenitor Cells.一种用于定量分析人类造血细胞系和造血干/祖细胞中 CRISPR/Cas9 诱导基因组编辑事件的多功能工具。
J Mol Biol. 2019 Jan 4;431(1):102-110. doi: 10.1016/j.jmb.2018.05.005. Epub 2018 May 9.
7
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.CtIP 融合 Cas9 通过同源依赖性修复增强转基因整合。
Nat Commun. 2018 Mar 19;9(1):1133. doi: 10.1038/s41467-018-03475-7.
8
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.对同源定向修复（HDR）和非同源末端连接（NHEJ）的系统定量揭示了基因座、核酸酶和细胞类型对基因组编辑的影响。
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9
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