Paajanen Pirita, Kimmey Jacqueline M, Dodd Antony N
John Innes Centre, Norwich Research Park, Norwich, UK.
Department of Microbiology and Environmental Toxicology, UC Santa Cruz, Santa Cruz, CA, USA.
Philos Trans R Soc Lond B Biol Sci. 2025 Jan 23;380(1918):20230346. doi: 10.1098/rstb.2023.0346.
Circadian clocks provide a biological measure of time that coordinates metabolism, physiology and behaviour with 24 h cycles in the environment. Circadian systems have a variety of characteristic properties, such as entrainment to environmental cues, a self-sustaining rhythm of about 24 h and temperature compensation of the circadian rhythm. In this perspective, we discuss the process of circadian gating, which refers to the restriction of a biological event to particular times of day by the circadian clock. We introduce principles and processes associated with circadian gating in a variety of organisms, including some associated mechanisms. We highlight socioeconomic opportunities presented by the investigation of circadian gating, using selected examples from circadian medicine and agricultural crop production to illustrate its importance.This article is part of the Theo Murphy meeting issue 'Circadian rhythms in infection and immunity'.
生物钟提供了一种时间的生物学度量，它能使新陈代谢、生理机能和行为与环境中的24小时周期相协调。昼夜节律系统具有多种特性，例如受环境线索的调节、约24小时的自我维持节律以及昼夜节律的温度补偿。在这篇综述中，我们讨论了昼夜节律门控的过程，它指的是生物钟将生物事件限制在一天中的特定时间。我们介绍了与多种生物体中昼夜节律门控相关的原理和过程，包括一些相关机制。我们利用昼夜节律医学和农作物生产中的特定例子来强调昼夜节律门控研究带来的社会经济机遇，以说明其重要性。本文是西奥·墨菲会议特刊“感染与免疫中的昼夜节律”的一部分。
