Belkin V M, Kukharenko V I, Volodarskaia S M, Grinberg K N, Mazurov V I
Vopr Med Khim. 1985 Jan-Feb;31(1):125-30.
Biosynthesis of fibronectin in 2 strains of aneuploid human fibroblasts with trisomy by chromosomes 7 and 9 was about 2-fold decreased as compared with normal diploid fibroblasts. The most distinct decrease of the fibronectin biosynthesis was observed at the logarithmic phase of the cell culture growth. The cells with anomalous karyotype exhibited also the decreased rate of secretion of the impulse labelled fibronectin. The decrease in the rate of fibronectin and collagen production (main proteins of intercellular substance) in fibroblasts with the chromosomes anomalies might be responsible for irreversible impairments of the embryo development, resulting in spontaneous abortion.
与正常二倍体成纤维细胞相比，7号和9号染色体三体的2株非整倍体人成纤维细胞中纤连蛋白的生物合成减少了约2倍。在细胞培养生长的对数期观察到纤连蛋白生物合成最明显的减少。具有异常核型的细胞还表现出脉冲标记的纤连蛋白分泌率降低。染色体异常的成纤维细胞中纤连蛋白和胶原蛋白（细胞间质的主要蛋白质）产生速率的降低可能是胚胎发育不可逆损伤的原因，导致自然流产。
