Hernandez Daniel, Nam Taewoo, Lee Eunwoo, Ryu Yeunchul, Chung Jun-Young, Kim Kyoung-Nam
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea.
Magn Reson Med Sci. 2025 Jan 23. doi: 10.2463/mrms.mp.2024-0086.
Hyperthermia is a treatment that applies heat to damage or kill cancer cells and can be also used for drug deliveries. It is important to apply the heat into the specific area in order to target the cancer tissue and avoid damaging healthy tissue. For this reason, the development of heat applicators that have the capability to deliver the heat to the target area is vital. In this study, we present an optimization of an array coil for brain hyperthermia that can be used in combination with MRI, such that the heat can be delivered to the cancer area.
The array coils were based on optimizing loop coils by varying the capacitor's position along the perimeter. The optimization was performed using electromagnetic simulations, by computing the electric field (E) and temperature inside of the brain and targeting tumor tissues for focus temperature application. The coils were compared with a general-use symmetric coil array for head heating.
The optimization of the coil array was able to focus electric field and make temperature rise at the cancer areas. The temperature in Tumor 1 before and after standard and the proposed method optimization was 43.6°C, 48.3°C, and 42.5°C and for Tumor 2 the temperatures were 44.2°C, 43.1°C, and 42.9°C, respectively. Although the standard optimization method exhibits higher temperatures, it also had higher temperatures outside the tumors area.
We demonstrated the optimization of array coils with different capacitor positions to obtain focused heating temperatures.
热疗是一种通过施加热量来损伤或杀死癌细胞的治疗方法，也可用于药物递送。为了靶向癌组织并避免损伤健康组织，将热量施加到特定区域非常重要。因此，开发能够将热量传递到目标区域的热 applicators 至关重要。在本研究中，我们展示了一种可与 MRI 结合使用的用于脑部热疗的阵列线圈的优化，从而能够将热量传递到癌区。
阵列线圈基于通过改变电容器沿周长的位置来优化环形线圈。使用电磁模拟进行优化，通过计算脑内的电场（E）和温度，并将肿瘤组织作为聚焦温度施加的目标。将这些线圈与用于头部加热的通用对称线圈阵列进行比较。
线圈阵列的优化能够聚焦电场并使癌区温度升高。标准方法和所提出方法优化前后，肿瘤 1 的温度分别为 43.6°C、48.3°C 和 42.5°C，肿瘤 2 的温度分别为 44.2°C、43.1°C 和 42.9°C。虽然标准优化方法显示出更高的温度，但在肿瘤区域外也有更高的温度。
我们展示了通过不同电容器位置优化阵列线圈以获得聚焦加热温度。
