How do Gram-negative bacteria escape predation by Bdellovibrio bacteriovorus?

Bdellovibrio bacteriovorus is a small predatory bacterium which reproduces by invading and killing Gram-negative bacteria. The natural antimicrobial activity of B. bacteriovorus has garnered interest for the potential to develop this predatory bacterium as a therapeutic agent. Transitioning B. bacteriovorus from 'bench to bedside' will require a complete understanding of all aspects of bacterial predation, including how prey species may escape predation. Here we discuss recent findings relating to how Gram-negative bacteria may escape predation.