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囊性纤维化中的多微生物感染以及改善脓肿分枝杆菌药物研发的未来展望。

Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery.

作者信息

Baker Emily J, Allcott Gemma, Cox Jonathan A G

机构信息

College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.

出版信息

NPJ Antimicrob Resist. 2024 Nov 14;2(1):38. doi: 10.1038/s44259-024-00060-5.

DOI:10.1038/s44259-024-00060-5
PMID:39843836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11721438/
Abstract

Polymicrobial communities inhabit the cystic fibrosis (CF) airway, whereby microbial interactions can occur. One prominent CF pathogen is Mycobacterium abscessus, whose treatment is largely unsuccessful. This creates a need to discover novel antimicrobial agents to treat M. abscessus, however the methods used within antibiotic discovery are typically monomicrobial. This review will discuss this pathogen whilst considering the CF polymicrobial environment, to highlight future perspectives to improve M. abscessus drug discovery.

摘要

多种微生物群落栖息于囊性纤维化（CF）气道中，从而可能发生微生物间的相互作用。一种主要的CF病原体是脓肿分枝杆菌，其治疗在很大程度上并不成功。这就需要发现新的抗菌剂来治疗脓肿分枝杆菌，然而抗生素发现中使用的方法通常是针对单一微生物的。本综述将在考虑CF多微生物环境的同时讨论这种病原体，以突出改善脓肿分枝杆菌药物发现的未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/36e97a452a02/44259_2024_60_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/7f3a2c1169e9/44259_2024_60_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/31264094a5d8/44259_2024_60_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/4ce079e97236/44259_2024_60_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/36e97a452a02/44259_2024_60_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/7f3a2c1169e9/44259_2024_60_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/31264094a5d8/44259_2024_60_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/4ce079e97236/44259_2024_60_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e904/11721438/36e97a452a02/44259_2024_60_Fig4_HTML.jpg

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