The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Public Health. 2024 Dec;237:410-417. doi: 10.1016/j.puhe.2024.10.032. Epub 2024 Nov 11.
The triglyceride glucose-body mass index (TyG-BMI) is a well-established surrogate marker for insulin resistance. While an association between insulin resistance and depression has been identified, that between TyG-BMI and depression remains unclear. Therefore, we used data from the National Health and Nutrition Examination Survey (NHANES) database to investigate this.
This cross-sectional study included 9673 adults (aged ≥20 years) from the NHANES in the United States from 2011 to 2020.
Depressive symptoms were assessed using a nine-item version of the Patient Health Questionnaire. The covariates included age, sex, race/ethnicity, marital status, educational level, poverty-income ratio, smoking status, alcohol intake, diabetes status, cardiovascular disease, hypertension, physical activity, high-density lipoprotein, low-density lipoprotein, and total cholesterol. Multivariate logistic regression models, subgroup analyses, and threshold saturation effect analyses were conducted.
After adjusting for age, sex, race/ethnicity, marital status, education level, poverty-income ratio, smoking status, drinking status, diabetes status, cardiovascular disease, hypertension, physical activity, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, the threshold saturation effect showed a TyG-BMI inflection point of 174.4. Below the inflection point, a 10-unit increase in TyG-BMI was associated with a 12 % lower prevalence of depression. Above the inflection point, each 10-unit increase in TyG-BMI was associated with a 4 % increase in prevalence of depression.
TyG-BMI had a U-shaped relationship with prevalence of depression. There was a significant link between higher TyG-BMI levels and increased prevalence of depression. When the TyG-BMI value was below 174.4, any further increase in TyG-BMI was associated with a significantly lower prevalence of depression.
甘油三酯-葡萄糖-体重指数（TyG-BMI）是胰岛素抵抗的一种成熟替代标志物。虽然已经确定了胰岛素抵抗与抑郁症之间存在关联，但 TyG-BMI 与抑郁症之间的关联尚不清楚。因此，我们使用了来自美国国家健康和营养调查（NHANES）数据库的数据来对此进行研究。
本横断面研究纳入了来自美国 2011 年至 2020 年 NHANES 的 9673 名成年人（年龄≥20 岁）。
使用患者健康问卷的九项版本评估抑郁症状。协变量包括年龄、性别、种族/民族、婚姻状况、教育程度、贫困收入比、吸烟状况、饮酒状况、糖尿病状况、心血管疾病、高血压、身体活动、高密度脂蛋白、低密度脂蛋白和总胆固醇。进行多变量逻辑回归模型、亚组分析和阈值饱和效应分析。
在调整年龄、性别、种族/民族、婚姻状况、教育程度、贫困收入比、吸烟状况、饮酒状况、糖尿病状况、心血管疾病、高血压、身体活动、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇后，阈值饱和效应显示 TyG-BMI 的拐点为 174.4。在拐点以下，TyG-BMI 增加 10 个单位与抑郁患病率降低 12%相关。在拐点以上，TyG-BMI 每增加 10 个单位与抑郁患病率增加 4%相关。
TyG-BMI 与抑郁患病率呈 U 型关系。较高的 TyG-BMI 水平与抑郁患病率增加之间存在显著关联。当 TyG-BMI 值低于 174.4 时，TyG-BMI 的任何进一步增加都与抑郁患病率显著降低相关。
