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在冠向复位瓣术后,羊膜与透明质酸用于牙龈退缩覆盖及临床附着水平增加的比较——一项临床研究

Comparison of Amnion Membrane and Hyaluronic Acid in Gingival Recession Coverage and Gain in Clinical Attachment Level following Coronally Advanced Flap Procedure-A Clinical Study.

作者信息

Bagde Hiroj, Pawar Sangeeta K, Vasisth Diwakar, Vadvadgi Vinay H, Laddha Rashmi B, Wagh Pradnya P

机构信息

Department of Periodontology, Rama Dental College, Kanpur, Uttar Pradesh, India.

Depertment of Oral Pathology, Dr. Hegdewar Smruti Rugna Seva Mandals Dental College and Hospital, Hingoli, Maharashtra, India.

出版信息

J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1104-S1107. doi: 10.4103/jpbs.jpbs_202_23. Epub 2023 Jul 11.

DOI:10.4103/jpbs.jpbs_202_23
PMID:37694043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485441/
Abstract

BACKGROUND

Gingival recession is defined as the apical migration of gingival margin to the cementoenamel junction. Recently, amnion membrane, the third-generation membrane which is a placental-derived tissue, has been introduced.

MATERIALS AND METHODS

Study included 45 subjects with age group of 20-60 years of both genders. Patients with Miller's Class I and Class II gingival recession were selected for the study. The progress was assessed at baseline one, three, and six months observation interval through clinical parameters RD, RW, PD, and CAL at the end of six months.

RESULTS

Recession depths in the first, third, and sixth month were 1.82 ± 0.442, 1.31 ± 0.47 mm, and 0.91 ± 0.29, respectively, which showed a significant reduction from the baseline. Recession widths in the first, second, and third weeks were 3.04 ± 0.442 mm, 1.31 ± 0.47 mm, and 1.49 ± 0.59 mm, respectively. There was a statistically significant reduction ( > 0.005) when compared to the baseline. Pocket depths in the first, third, and sixth month were 0.93 ± 0.447, 0.42 ± 0.50, and 0.24 ± 0.43 ( > 0.005) which is significant when compared to baseline. Clinical attachment levels in the first, third, and sixth month were 2.73 ± 0.751, 1.78 ± 0.70, and 1.18 ± 0.53 ( > 0.005) which is significant compared to six months.

CONCLUSION

Within the limitations of the present study, the data obtained by periodic assessment of the clinical parameters indicate the use of amnion membrane and hyaluronic acid, and proper technique may thus be the panacea for root coverage procedure.

摘要

背景

牙龈退缩被定义为牙龈边缘向牙骨质釉质界的根尖方向迁移。最近,羊膜,一种源自胎盘组织的第三代膜,已被引入。

材料与方法

研究纳入了45名年龄在20至60岁之间的男女受试者。选择患有米勒I类和II类牙龈退缩的患者进行研究。在基线、1个月、3个月和6个月的观察间隔期,通过临床参数RD、RW、PD和CAL对进展情况进行评估,在6个月末进行评估。

结果

第1个月、第3个月和第6个月的退缩深度分别为1.82±0.442、1.31±0.47毫米和0.91±0.29,与基线相比有显著降低。第1周、第2周和第3周的退缩宽度分别为3.04±0.442毫米、1.31±0.47毫米和1.49±0.59毫米。与基线相比,有统计学上的显著降低(>0.005)。第1个月、第3个月和第6个月的袋深分别为0.93±0.447、0.42±0.50和0.24±0.43(>0.005),与基线相比有显著差异。第1个月、第3个月和第6个月的临床附着水平分别为2.73±0.751、1.78±0.70和1.18±0.53(>0.005),与6个月时相比有显著差异。

结论

在本研究的局限性范围内,通过定期评估临床参数获得的数据表明,使用羊膜和透明质酸以及适当的技术可能是根面覆盖手术的万灵药。

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本文引用的文献

1
Human Amnion Membrane: Potential Applications in Oral and Periodontal Field.人羊膜:在口腔及牙周领域的潜在应用
J Int Soc Prev Community Dent. 2017 Jan-Feb;7(1):15-21. doi: 10.4103/jispcd.JISPCD_359_16. Epub 2017 Feb 21.
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Amniotic membrane - A Novel material for the root coverage: A case series.羊膜——一种用于牙根覆盖的新型材料:病例系列
J Indian Soc Periodontol. 2015 Jul-Aug;19(4):444-8. doi: 10.4103/0972-124X.154166.
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Efficacy of hyaluronic acid (hyaluronan) in root coverage procedures as an adjunct to coronally advanced flap in Millers Class I recession: A clinical study.透明质酸在米勒I类牙龈退缩根面覆盖手术中作为冠向复位瓣辅助材料的疗效:一项临床研究。
J Indian Soc Periodontol. 2014 Nov-Dec;18(6):746-50. doi: 10.4103/0972-124X.147411.
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Comparison of amnion allograft with connective tissue graft for root coverage procedures: a double-blind, randomized, controlled clinical trial.羊膜同种异体移植与结缔组织移植用于牙根覆盖手术的比较:一项双盲、随机、对照临床试验。
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Long-term outcome following treatment of multiple Miller class I and II recession defects in esthetic areas of the mouth.口腔美学区域多个Miller I类和II类牙龈退缩缺损治疗后的长期疗效
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Periodontal diseases.牙周疾病
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Factors affecting the outcomes of coronally advanced flap root coverage procedure.影响冠向复位瓣根面覆盖术效果的因素。
J Periodontol. 2005 Oct;76(10):1729-34. doi: 10.1902/jop.2005.76.10.1729.
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Function of laminins and laminin-binding integrins in gingival epithelial cell adhesion.层粘连蛋白及层粘连蛋白结合整合素在牙龈上皮细胞黏附中的作用
J Periodontol. 2002 Jul;73(7):709-19. doi: 10.1902/jop.2002.73.7.709.
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Dent Update. 2002 Apr;29(3):144-8. doi: 10.12968/denu.2002.29.3.144.