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N-lactoyl phenylalanine suppresses appetite and obesity with important implications for aging and age-related diseases.

作者信息

Hinton Antentor, Neikirk Kit, Le Han, Oliver Ashton, Harris Chanel, Martin Pamela, Gaye Amadou

机构信息

Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.

Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Sciences, Meharry Medical College, Nashville, TN, USA.

出版信息

Aging Adv. 2024 Dec;1(2):172-173. doi: 10.4103/agingadv.agingadv-d-24-00011. Epub 2024 Dec 20.

DOI:10.4103/agingadv.agingadv-d-24-00011
PMID:39845129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11752169/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/11752169/8c47175ea05d/nihms-2046181-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/11752169/8c47175ea05d/nihms-2046181-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/11752169/8c47175ea05d/nihms-2046181-f0001.jpg

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本文引用的文献

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The clinical relevance of novel biomarkers as outcome parameter in adults with phenylketonuria.新型生物标志物作为成人苯丙酮尿症结局参数的临床相关性。
J Inherit Metab Dis. 2024 Jul;47(4):624-635. doi: 10.1002/jimd.12732. Epub 2024 Mar 31.
2
Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport.敲除人近端肾小管细胞中的二肽酶 CN2 会破坏二肽和氨基酸的稳态以及细胞旁和跨细胞溶质转运。
Acta Physiol (Oxf). 2024 Apr;240(4):e14126. doi: 10.1111/apha.14126. Epub 2024 Mar 22.
3
Lac-Phe mediates the effects of metformin on food intake and body weight.
Lac-Phe 介导二甲双胍对食物摄入和体重的影响。
Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18.
4
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.二甲双胍和进食增加了人类中抑制食欲的代谢物 Lac-Phe 的水平。
Nat Metab. 2024 Apr;6(4):651-658. doi: 10.1038/s42255-024-01018-7. Epub 2024 Mar 18.
5
Mitochondria in disease: changes in shapes and dynamics.线粒体在疾病中的作用：形态和动力学的变化。
Trends Biochem Sci. 2024 Apr;49(4):346-360. doi: 10.1016/j.tibs.2024.01.011. Epub 2024 Feb 23.
6
Organ aging signatures in the plasma proteome track health and disease.血浆蛋白质组中的器官衰老特征可跟踪健康和疾病。
Nature. 2023 Dec;624(7990):164-172. doi: 10.1038/s41586-023-06802-1. Epub 2023 Dec 6.
7
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JCI Insight. 2023 Oct 9;8(19):e171225. doi: 10.1172/jci.insight.171225.
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