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1
Lac-Phe (N-lactoyl-phenylalanine).Lac-Phe（N-乳酰苯丙氨酸）。
Trends Endocrinol Metab. 2024 Aug;35(8):758-759. doi: 10.1016/j.tem.2024.05.007. Epub 2024 Jul 13.
2
Comparative Analysis of -Lactoyl-phenylalanine and 3-Phenyllactic Acid Production in Lactic Acid Bacteria from Kimchi: Metabolic Insights and Influencing Factors.泡菜乳酸菌中β-乳酰苯丙氨酸和3-苯乳酸产生的比较分析：代谢见解与影响因素
J Agric Food Chem. 2024 Dec 11;72(49):27177-27186. doi: 10.1021/acs.jafc.4c07158. Epub 2024 Nov 28.
3
Rapid indirect detection of N-lactoyl-phenylalanine using dual DNA biosensors based on solution-gated graphene field-effect transistor.基于溶液栅控石墨烯场效应晶体管的双DNA生物传感器快速间接检测N-乳酰苯丙氨酸
Biosens Bioelectron. 2025 Apr 1;273:117149. doi: 10.1016/j.bios.2025.117149. Epub 2025 Jan 10.
4
Preparation and Taste Characteristics of Kokumi -Lactoyl Phenylalanine in the Presence of Phenylalanine and Lactate.在苯丙氨酸和乳酸存在下的 kokumi-乳酰苯丙氨酸的制备和口感特性。
J Agric Food Chem. 2022 May 4;70(17):5396-5407. doi: 10.1021/acs.jafc.2c00530. Epub 2022 Apr 22.
5
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization Via the Suppression of the NF-κB Signaling Pathway.运动诱导的代谢产物N-乳酰苯丙氨酸通过抑制NF-κB信号通路来抑制M1巨噬细胞极化从而改善结肠炎。
Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558. doi: 10.1016/j.jcmgh.2025.101558.
6
SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans.SLC17A1/3 转运体介导了 Lac-Phe 在小鼠和人体内的肾脏排泄。
Nat Commun. 2024 Aug 12;15(1):6895. doi: 10.1038/s41467-024-51174-3.
7
Lac-Phe mediates the effects of metformin on food intake and body weight.Lac-Phe 介导二甲双胍对食物摄入和体重的影响。
Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18.
8
Outrunning obesity with Lac-Phe?用 Lac-Phe 跑赢肥胖症？
Cell Metab. 2022 Aug 2;34(8):1085-1087. doi: 10.1016/j.cmet.2022.07.007.
9
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.二甲双胍和进食增加了人类中抑制食欲的代谢物 Lac-Phe 的水平。
Nat Metab. 2024 Apr;6(4):651-658. doi: 10.1038/s42255-024-01018-7. Epub 2024 Mar 18.
10
An exercise-inducible metabolite that suppresses feeding and obesity.一种可诱导运动的代谢物，可抑制进食和肥胖。
Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15.

引用本文的文献

1
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.N-乳酰苯丙氨酸通过AMPK-PGC1α-PPARγ途径调节小胶质细胞/巨噬细胞中的脂质代谢，以促进脊髓损伤小鼠的恢复。
J Neuroinflammation. 2025 Jun 27;22(1):167. doi: 10.1186/s12974-025-03495-3.
2
High-Calorie Diet Consumption Induces Lac-Phe Changes in the Brain in a Time-of-Day Manner Independent of Exercise.高热量饮食的摄入会以一种与运动无关的、按一天中的时间变化的方式诱导大脑中Lac-Phe的变化。
Metabolites. 2025 Jun 6;15(6):375. doi: 10.3390/metabo15060375.
3
Exercise, Neuroprotective Exerkines, and Parkinson's Disease: A Narrative Review.运动、神经保护外泌体与帕金森病：叙述性综述。
Biomolecules. 2024 Sep 30;14(10):1241. doi: 10.3390/biom14101241.

本文引用的文献

1
Lac-Phe mediates the effects of metformin on food intake and body weight.Lac-Phe 介导二甲双胍对食物摄入和体重的影响。
Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18.
2
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.二甲双胍和进食增加了人类中抑制食欲的代谢物 Lac-Phe 的水平。
Nat Metab. 2024 Apr;6(4):651-658. doi: 10.1038/s42255-024-01018-7. Epub 2024 Mar 18.
3
Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock.循环 N-脂酰基-氨基酸和 N-甲酰基-甲硫氨酸反映线粒体功能障碍，并可预测脓毒性休克患者的死亡率。
Metabolomics. 2024 Mar 6;20(2):36. doi: 10.1007/s11306-024-02089-z.
4
Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans.运动诱导的N-乳酰苯丙氨酸可预测超重和肥胖人群耐力训练期间的脂肪组织减少。
Metabolites. 2022 Dec 22;13(1):15. doi: 10.3390/metabo13010015.
5
An exercise-inducible metabolite that suppresses feeding and obesity.一种可诱导运动的代谢物，可抑制进食和肥胖。
Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15.
6
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.循环 NADH 还原应激标志物与线粒体疾病严重程度相关。
J Clin Invest. 2021 Jan 19;131(2). doi: 10.1172/JCI136055.
7
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics.通过平行体内代谢组学进行酶途径的全家族注释。
Cell Chem Biol. 2019 Nov 21;26(11):1623-1629.e3. doi: 10.1016/j.chembiol.2019.09.009. Epub 2019 Oct 3.
8
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.N-乳酰氨基酸是普遍存在的代谢产物，它们源自CNDP2介导的乳酸和氨基酸的逆向蛋白水解作用。
Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6. doi: 10.1073/pnas.1424638112. Epub 2015 May 11.

Lac-Phe (N-lactoyl-phenylalanine).

作者信息

Xiao Shuke, Li Veronica L, Long Jonathan Z

机构信息

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Sarafan ChEM-H, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Sarafan ChEM-H, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA; Department of Chemistry, Stanford University, Stanford, CA, USA; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA.

出版信息

Trends Endocrinol Metab. 2024 Aug;35(8):758-759. doi: 10.1016/j.tem.2024.05.007. Epub 2024 Jul 13.

DOI:10.1016/j.tem.2024.05.007
PMID:39137723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446501/
Abstract
摘要