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Lac-Phe (N-lactoyl-phenylalanine).

作者信息

Xiao Shuke, Li Veronica L, Long Jonathan Z

机构信息

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Sarafan ChEM-H, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Sarafan ChEM-H, Stanford University, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA; Department of Chemistry, Stanford University, Stanford, CA, USA; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA.

出版信息

Trends Endocrinol Metab. 2024 Aug;35(8):758-759. doi: 10.1016/j.tem.2024.05.007. Epub 2024 Jul 13.

Abstract
摘要

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本文引用的文献

1
Lac-Phe mediates the effects of metformin on food intake and body weight.
Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18.
2
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Nat Metab. 2024 Apr;6(4):651-658. doi: 10.1038/s42255-024-01018-7. Epub 2024 Mar 18.
5
An exercise-inducible metabolite that suppresses feeding and obesity.
Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15.
7
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics.
Cell Chem Biol. 2019 Nov 21;26(11):1623-1629.e3. doi: 10.1016/j.chembiol.2019.09.009. Epub 2019 Oct 3.
8
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.
Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6. doi: 10.1073/pnas.1424638112. Epub 2015 May 11.

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