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蒌叶对雄性斯普拉格-道利大鼠高脂饮食诱导和氧化偶氮甲烷诱导的结肠癌的化学预防作用。

Chemopreventive Effects of Piper betle (Sirih) on High-Fat Diet-Induced and Azoxymethane-Induced Colon Cancer in Male Sprague-Dawley Rats.

作者信息

Roslan Nur Hazirah, Zarkasi Khairul Anwar, Mohd Yusof Yasmin Anum, Makpol Suzana

机构信息

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.

Biochemistry Unit, Preclinical Department, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia, Kuala Lumpur, MYS.

出版信息

Cureus. 2024 Dec 23;16(12):e76260. doi: 10.7759/cureus.76260. eCollection 2024 Dec.

DOI:10.7759/cureus.76260
PMID:39845239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11753357/
Abstract

A high-fat diet could lead to obesity, increasing colorectal cancer risk due to dyslipidemia and chronic inflammation, while Piper betle (PB) exhibits anti-tumor, anti-inflammation, and anti-oxidant benefits. This study aimed to determine whether PB possesses chemopreventive effects on high-fat diet (HFD)-induced and azoxymethane (AOM)-induced colon cancer. Male Sprague-Dawley rats receiving either a normal diet or HFD were divided into control, PB, AOM, and AOM+PB subgroups which were then sacrificed after 24 weeks. The lipid profile, leptin, and inflammatory markers were measured from serum, and aberrant crypt foci (ACF) in the colon were detected by methylene blue staining. Cellular proliferation was identified through immunohistochemical staining of antigen Kiel 67 (Ki67) and beta-catenin. There were significant differences in serum total cholesterol, low-density lipoprotein, triglycerides, and high-density lipoprotein in the HFD compared to the normal diet group. The AOM group for normal diet and HFD exhibited significantly increased serum leptin, interleukin-6, IL-12p70, tumor necrosis factor-α, and nuclear factor-κB, with overexpression of Ki67 and beta-catenin. These changes were reversed by PB supplementation. In conclusion, PB demonstrated lipid-modifying and chemopreventive effects against HFD and AOM-induced colon cancer in rats.

摘要

高脂饮食会导致肥胖，因血脂异常和慢性炎症增加患结直肠癌的风险，而蒌叶（PB）具有抗肿瘤、抗炎和抗氧化作用。本研究旨在确定PB对高脂饮食（HFD）诱导和氧化偶氮甲烷（AOM）诱导的结肠癌是否具有化学预防作用。将接受正常饮食或HFD的雄性Sprague-Dawley大鼠分为对照组、PB组、AOM组和AOM+PB亚组，24周后处死。检测血清中的血脂、瘦素和炎症标志物，并通过亚甲蓝染色检测结肠中的异常隐窝灶（ACF）。通过抗原Kiel 67（Ki67）和β-连环蛋白的免疫组织化学染色鉴定细胞增殖。与正常饮食组相比，HFD组的血清总胆固醇、低密度脂蛋白、甘油三酯和高密度脂蛋白存在显著差异。正常饮食和HFD的AOM组血清瘦素、白细胞介素-6、IL-12p70、肿瘤坏死因子-α和核因子-κB显著升高，Ki67和β-连环蛋白过度表达。补充PB可逆转这些变化。总之，PB对大鼠HFD和AOM诱导的结肠癌具有脂质调节和化学预防作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/ec6cab6cef01/cureus-0016-00000076260-i11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/ec6cab6cef01/cureus-0016-00000076260-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/6eec7901c45e/cureus-0016-00000076260-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/a8e990210874/cureus-0016-00000076260-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/5980ef7965a0/cureus-0016-00000076260-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/12992d25de48/cureus-0016-00000076260-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/d104eb6feaba/cureus-0016-00000076260-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/ce705289a596/cureus-0016-00000076260-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/433fe7dc8101/cureus-0016-00000076260-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/f71bd3dc35a2/cureus-0016-00000076260-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/dc38b4655092/cureus-0016-00000076260-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/ad94188e051a/cureus-0016-00000076260-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c5/11753357/ec6cab6cef01/cureus-0016-00000076260-i11.jpg

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