Modzelewska Patrycja, Chludzińska Sylwia, Lewko Jolanta, Reszeć Joanna
Department of Integrated Medical Care, Medical University of Bialystok, Poland.
Department of Medical Pathomorphology, Medical University of Bialystok, Poland.
Contemp Oncol (Pozn). 2019;23(2):63-68. doi: 10.5114/wo.2019.85877. Epub 2019 Jun 13.
Obesity is a new risk factor, to which more and more research is devoted, related to the development of cancer. Many studies of recent years have drawn attention to the role of adipose tissue as an important internal endocrine organ. In the adipose tissue proteins are produced, referred to by the common name as adipokines. In the case of obesity, the neoplasm cells are constantly stimulated by pro-inflammatory cytokines and adipokines, among which leptin dominates. The studies show that leptin can affect the cancer cells through numerous phenomena, e.g. inflammation, cell proliferation, suppression of apoptosis and angiogenesis. In this literature review we examined the role of leptin in the development of the individual cancers: breast cancer, colorectal cancer, prostate cancer, ovarian cancer, endometrial cancer and brain neoplasms: glioma and meningioma. However, leptin has very complicated mechanisms of action which require better understanding in certain types of cancer.
肥胖是一种新的风险因素，越来越多的研究致力于探讨其与癌症发生发展的关系。近年来，许多研究都关注到脂肪组织作为重要的体内内分泌器官所起的作用。脂肪组织会产生蛋白质，这些蛋白质统称为脂肪因子。在肥胖情况下，肿瘤细胞会持续受到促炎细胞因子和脂肪因子的刺激，其中瘦素起主导作用。研究表明，瘦素可通过多种现象影响癌细胞，如炎症、细胞增殖、抑制细胞凋亡和血管生成。在这篇文献综述中，我们研究了瘦素在各类癌症发生发展中的作用：乳腺癌、结直肠癌、前列腺癌、卵巢癌、子宫内膜癌以及脑肿瘤：胶质瘤和脑膜瘤。然而，瘦素的作用机制非常复杂，在某些类型的癌症中还需要更深入的了解。
