Evaluation of the significance of single nucleotide polymorphisms of the gene as biomarkers of hepatological complications in Epstein-Barr virus infection in children.

AIM OF THE STUDY

To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 () gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.

MATERIAL AND METHODS

The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the gene.

RESULTS

It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.

CONCLUSIONS

The rs2287622 polymorphism of the gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.