Moppert Justyna, Domagalski Krzysztof, Pawłowska Małgorzata
Department of Infectious Diseases and Hepatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Department of Paediatrics, Infectious Diseases and Hepatology, Voivodeship Infectious Observation Hospital in Bydgoszcz, Poland.
Clin Exp Hepatol. 2024 Mar;10(2):104-110. doi: 10.5114/ceh.2024.140450. Epub 2024 Jun 11.
To evaluate single nucleotide polymorphisms of the adenosine triphosphate (ATP) binding cassette subfamily B member 11 () gene, rs11568364 and rs2287622, as potential predictors of hepatologic complications during Epstein-Barr virus (EBV) infection among children.
The study group consisted of 54 children aged 1 to 18 years hospitalised from 01.12.2018 to 31.12.2020 in the Department of Paediatrics, Infectious Diseases and Hepatology with hepatological complications in the course of serologically and molecularly confirmed EBV infection. Real-time PCR using TaqMan probes was used to determine single-nucleotide variability in the gene.
It was found that the presence of the T allele for the rs2287622 marker increases the probability of hepatitis three times and the possibility of hepatitis with cholestasis almost four times in EBV-infected patients.
The rs2287622 polymorphism of the gene appears to have an impact on the occurrence of hepatological complications in the course of EBV infection in children.
评估三磷酸腺苷（ATP）结合盒亚家族B成员11（）基因的单核苷酸多态性rs11568364和rs2287622，作为儿童感染爱泼斯坦-巴尔病毒（EBV）期间肝脏并发症的潜在预测指标。
研究组由2018年12月1日至2020年12月31日在儿科、传染病和肝病科住院的54名1至18岁儿童组成，这些儿童在血清学和分子学确诊的EBV感染过程中出现肝脏并发症。使用TaqMan探针的实时聚合酶链反应用于确定基因中的单核苷酸变异性。
发现rs2287622标记的T等位基因的存在使EBV感染患者患肝炎的概率增加三倍，患胆汁淤积性肝炎的可能性增加近四倍。
基因的rs2287622多态性似乎对儿童EBV感染过程中肝脏并发症的发生有影响。
