Moppert Justyna, Domagalski Krzysztof, Wrotek Sylwia, Pawłowska Małgorzata
Department of Infectious Diseases and Hepatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 87-100 Toruń, Poland.
Department of Paediatrics, Infectious Diseases and Hepatology, Voivodeship Infectious Observation Hospital in Bydgoszcz, 85-030 Bydgoszcz, Poland.
J Clin Med. 2023 Sep 24;12(19):6158. doi: 10.3390/jcm12196158.
The aim of the study was to evaluate tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), soluble intracellular adhesion molecules 1 (s-ICAM-1) and Epstein-Barr virus (EBV) DNA load levels as predictors of hepatological complications of EBV infection in children. The study group consisted of 54 children aged one to eighteen years, who were hospitalised from 1 December 2018 to 31 December 2020 in the Department of Paediatrics, Infectious Diseases and Hepatology and who had hepatological complications in the course of serologically and molecularly confirmed EBV infection. It was shown that IL-6, TNF-α, and s-ICAM-1 concentrations were the highest in patients with hepatitis and biliary pole damage. Higher EBV DNA viremia positively correlated with increased C-reactive protein (CRP) and TNF-α levels and increased leukocyte, lymphocyte, and monocyte counts. Increases in lymphocyte counts and TNF-α concentrations were observed along with increases in gamma-glutamyl transpeptidase (GGTP) activity. Increased concentrations of IL-6, TNF-α, and s-ICAM-1 may indicate the risk of hepatitis with concomitant biliary pole damage during EBV infection.
本研究的目的是评估肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、可溶性细胞间黏附分子1（s-ICAM-1）和爱泼斯坦-巴尔病毒（EBV）DNA载量水平，作为儿童EBV感染肝脏并发症的预测指标。研究组由54名年龄在1至18岁之间的儿童组成，他们于2018年12月1日至2020年12月31日在儿科、传染病和肝病科住院，且在血清学和分子学确诊的EBV感染过程中出现了肝脏并发症。结果显示，肝炎和胆管损伤患者的IL-6、TNF-α和s-ICAM-1浓度最高。较高的EBV DNA病毒血症与C反应蛋白（CRP）和TNF-α水平升高以及白细胞、淋巴细胞和单核细胞计数增加呈正相关。随着γ-谷氨酰转肽酶（GGTP）活性增加，观察到淋巴细胞计数和TNF-α浓度升高。IL-6、TNF-α和s-ICAM-1浓度升高可能表明EBV感染期间伴有胆管损伤的肝炎风险。
