Xin Yuejiao, Wang Yixiang
Department of Periodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China.
Oral Dis. 2025 Jan 23. doi: 10.1111/odi.15248.
To review current knowledge of the various processes of programmed cell death and their roles in immunoregulation in periodontitis.
Relevant literature in the PubMed, Medline, and Scopus databases was searched, and a narrative review was performed. Programmed cell death and the regulation of its various pathways implicated in periodontal infection were reviewed.
Multicellular organisms dispose of unnecessary or damaged cells via programmed cell death. Programmed cell death lies at the core of the balance of cell death and survival in pathological progress and infection. Periodontitis is a complex infectious disease involving virulence factors of periodontal pathogens and tightly regulated immune responses of the host. Different types of programmed cell death can play opposite roles in periodontitis or exert their action combinatorially.
The coordinated system of various programmed cell death pathways and the extensive crosstalk among them play a fundamental role in the pathophysiology of periodontitis. Illuminating the precise roles and mechanisms of programmed cell death in periodontitis could open up novel therapeutic approaches.
综述程序性细胞死亡的各种过程及其在牙周炎免疫调节中的作用的现有知识。
检索PubMed、Medline和Scopus数据库中的相关文献，并进行叙述性综述。对程序性细胞死亡及其与牙周感染相关的各种途径的调节进行了综述。
多细胞生物通过程序性细胞死亡清除不必要或受损的细胞。程序性细胞死亡是病理进展和感染中细胞死亡与存活平衡的核心。牙周炎是一种复杂的感染性疾病，涉及牙周病原体的毒力因子和宿主严格调节的免疫反应。不同类型的程序性细胞死亡在牙周炎中可能发挥相反的作用，或联合发挥作用。
各种程序性细胞死亡途径的协调系统及其之间广泛的相互作用在牙周炎的病理生理学中起重要作用。阐明程序性细胞死亡在牙周炎中的精确作用和机制可能会开辟新的治疗方法。
