长链非编码RNA在银屑病发病机制中的作用

The Role of Long Non-Coding RNA in the Pathogenesis of Psoriasis.

作者信息

Kiełbowski Kajetan, Jędrasiak Anna, Bakinowska Estera, Pawlik Andrzej

机构信息

Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.

出版信息

Noncoding RNA. 2025 Jan 17;11(1):7. doi: 10.3390/ncrna11010007.

DOI:10.3390/ncrna11010007

PMID:39846685

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11755624/

Abstract

Psoriasis is a chronic immune-mediated disease with complex pathogenesis. The altered proliferation and differentiation of keratinocytes, together with the activity of dendritic cells and T cells, are crucial drivers of psoriasis progression. Long non-coding RNAs (lncRNAs) are composed of over 200 nucleotides and exert a large variety of functions, including the regulation of gene expression. Under pathological conditions, the expression of lncRNAs is frequently dysregulated. Recent studies demonstrated that lncRNAs significantly affect major cellular processes, and their aberrant expression is likely involved in the pathogenesis of various disorders. In this review, we will discuss the role of lncRNAs in the pathophysiology of psoriasis. We will summarize recent studies that investigated the relationships between lncRNAs and keratinocyte proliferation and pro-inflammatory responses.

摘要

银屑病是一种发病机制复杂的慢性免疫介导性疾病。角质形成细胞增殖和分化的改变，以及树突状细胞和T细胞的活性，是银屑病进展的关键驱动因素。长链非编码RNA（lncRNA）由超过200个核苷酸组成，并发挥多种功能，包括基因表达调控。在病理条件下，lncRNA的表达经常失调。最近的研究表明，lncRNA显著影响主要细胞过程，其异常表达可能参与了各种疾病的发病机制。在这篇综述中，我们将讨论lncRNA在银屑病病理生理学中的作用。我们将总结最近研究中关于lncRNA与角质形成细胞增殖和促炎反应之间关系的研究。