Avecilla Vincent, Doke Mayur, Appunni Sandeep, Rubens Muni, Ramamoorthy Venkataraghavan, Das Jayanta Kumar
Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL 33199, USA.
Avecilla Consulting LLC, Miami, FL 33131, USA.
Med Sci (Basel). 2024 Dec 26;13(1):2. doi: 10.3390/medsci13010002.
Vascular diseases, such as hypertension, atherosclerosis, cerebrovascular, and peripheral arterial diseases, present major clinical and public health challenges, largely due to their common underlying process: vascular remodeling. This process involves structural alterations in blood vessels, driven by a variety of molecular mechanisms. The inhibitor of DNA-binding/differentiation-3 (), a crucial member of ID family of transcriptional regulators, has been identified as a key player in vascular biology, significantly impacting the progression of these diseases. This review explores the role of in vascular remodeling, emphasizing its involvement in processes such as apoptosis, cell proliferation, and extracellular matrix regulation. Furthermore, we examine how oxidative stress, intensified by exposure to estrogenic endocrine disruptors (EEDs) like polychlorinated biphenyls (PCBs) and bisphenol A (BPA), affects activity and contributes to vascular disease. Understanding the interaction between signaling and EED exposure provides critical insights into the molecular mechanisms underlying vascular remodeling and its role in the development and progression of vascular diseases.
血管疾病，如高血压、动脉粥样硬化、脑血管疾病和外周动脉疾病，构成了重大的临床和公共卫生挑战，这主要是由于它们共同的潜在过程：血管重塑。这个过程涉及血管的结构改变，由多种分子机制驱动。DNA结合/分化抑制因子3（ID3）是转录调节因子ID家族的关键成员，已被确定为血管生物学中的关键角色，对这些疾病的进展有重大影响。本综述探讨了ID3在血管重塑中的作用，强调其参与凋亡、细胞增殖和细胞外基质调节等过程。此外，我们研究了暴露于多氯联苯（PCBs）和双酚A（BPA）等雌激素内分泌干扰物（EEDs）所加剧的氧化应激如何影响ID3活性并导致血管疾病。了解ID3信号传导与EED暴露之间的相互作用，为深入了解血管重塑的分子机制及其在血管疾病发生和发展中的作用提供了关键见解。
