Claes L, Burri C, Gerngross H, Mutschler W
Acta Orthop Scand. 1985 Feb;56(1):57-62. doi: 10.3109/17453678508992981.
Sheep had their right metatarsals osteotomized midshaft and stabilized by plate and screws. One group was injected with 1250 units of Factor Thirteen for 9 days postoperatively, and a control group received placebo injections. After 8 weeks, the bones were evaluated biomechanically, histomorphologically and by densitometry. The bones of the treated group had a significantly higher tensile strength than the bones of the control animals. The correlation of biomechanical and morphological results demonstrated that the tensile strength increased with an increasing number of osteons crossing the osteotomy gap. The hydroxyapatite content of the bone healing zone was 7.3 per cent higher for the treated bones than for the control bones.
将绵羊的右跖骨在骨干中部进行截骨，并使用钢板和螺钉进行固定。一组在术后9天注射1250单位的凝血因子XIII，对照组则接受安慰剂注射。8周后，对骨骼进行生物力学、组织形态学和骨密度测量评估。治疗组的骨骼拉伸强度明显高于对照动物的骨骼。生物力学和形态学结果的相关性表明，拉伸强度随着穿过截骨间隙的骨单位数量增加而增加。治疗组骨骼愈合区的羟基磷灰石含量比对照组骨骼高7.3%。
