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The Art(ery) of Contraction: Using Precision-Cut Lung Slices to Model Pulmonary Hypertension in Acute Respiratory Distress Syndrome.收缩的“艺术”：利用精密切割肺片模拟急性呼吸窘迫综合征中的肺动脉高压
Am J Respir Cell Mol Biol. 2025 Jul;73(1):1-2. doi: 10.1165/rcmb.2024-0603ED.
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LPS Increases Artery but Not Airway Contraction in Precision-Cut Lung Slices from a Mouse Model of Acute Respiratory Distress Syndrome.脂多糖增加急性呼吸窘迫综合征小鼠模型的精密肺切片中的动脉收缩，但不增加气道收缩。
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Partial liquid ventilation for the prevention of mortality and morbidity in paediatric acute lung injury and acute respiratory distress syndrome.部分液体通气预防小儿急性肺损伤和急性呼吸窘迫综合征的死亡率和发病率
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本文引用的文献

1
LPS Increases Artery but Not Airway Contraction in Precision-Cut Lung Slices from a Mouse Model of Acute Respiratory Distress Syndrome.脂多糖增加急性呼吸窘迫综合征小鼠模型的精密肺切片中的动脉收缩，但不增加气道收缩。
Am J Respir Cell Mol Biol. 2025 Jul;73(1):26-36. doi: 10.1165/rcmb.2024-0249OC.
2
Acute respiratory distress syndrome.急性呼吸窘迫综合征。
BMJ. 2024 Oct 28;387:e076612. doi: 10.1136/bmj-2023-076612.
3
Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery.精准切取肺切片：用于研究肺生理学、药理学、疾病发病机制和药物发现的一体化离体模型。
Respir Res. 2024 Jun 1;25(1):231. doi: 10.1186/s12931-024-02855-6.
4
Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88.无细胞血红蛋白通过 TLR4 和 MyD88 触发巨噬细胞细胞因子的产生。
Am J Physiol Lung Cell Mol Physiol. 2024 Jan 1;326(1):L29-L38. doi: 10.1152/ajplung.00123.2023. Epub 2023 Nov 22.
5
Impact of Plasma 5 Hydroxyindoleacetic Acid, a Serotonin Metabolite, on Clinical Severity in Acute Respiratory Distress Syndrome.血清素代谢产物血浆5-羟吲哚乙酸对急性呼吸窘迫综合征临床严重程度的影响。
Front Med (Lausanne). 2021 Dec 16;8:785409. doi: 10.3389/fmed.2021.785409. eCollection 2021.
6
Thromboxane A2 exacerbates acute lung injury via promoting edema formation.血栓素 A2 通过促进水肿形成加重急性肺损伤。
Sci Rep. 2016 Aug 26;6:32109. doi: 10.1038/srep32109.
7
Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension.肺血管壁僵硬：肺动脉高压导致右心室后负荷增加的一个重要因素。
Pulm Circ. 2011 Apr-Jun;1(2):212-23. doi: 10.4103/2045-8932.83453.
8
Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury.肺血管功能障碍与急性肺损伤患者的不良预后相关。
Am J Respir Crit Care Med. 2010 Nov 1;182(9):1123-8. doi: 10.1164/rccm.201002-0250OC. Epub 2010 Jun 17.
9
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.失血性休克增强肺内皮细胞活化：Toll样受体4和Toll样受体2的时间性改变的作用
Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1670-80. doi: 10.1152/ajpregu.00445.2009. Epub 2009 Oct 14.
10
Animal models of acute lung injury.急性肺损伤的动物模型
Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L379-99. doi: 10.1152/ajplung.00010.2008. Epub 2008 Jul 11.

The Art(ery) of Contraction: Using Precision-Cut Lung Slices to Model Pulmonary Hypertension in Acute Respiratory Distress Syndrome.

作者信息

Ford Maria L, Ruwanpathirana Anushka, Britt Rodney D

机构信息

Center for Perinatal Research The Abigail Wexner Research Institute at Nationwide Children's Hospital Columbus, Ohio.

Biomedical Sciences Graduate Program The Ohio State University Columbus, Ohio.

出版信息

Am J Respir Cell Mol Biol. 2025 Jul;73(1):1-2. doi: 10.1165/rcmb.2024-0603ED.

DOI:10.1165/rcmb.2024-0603ED
PMID:39847709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12254683/
Abstract
摘要