Tanaka Takeshi, Mori Masahiko, Tashiro Masato, Izumikawa Koichi
Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan.
Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Front Med (Lausanne). 2021 Dec 16;8:785409. doi: 10.3389/fmed.2021.785409. eCollection 2021.
Acute respiratory distress syndrome (ARDS) is characterized by dysregulated vascular permeability. The clinical outcomes remain poor, and the disease burden is widespread. We demonstrated that plasma 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, is a pivotal severity indicator of ARDS. Serotonin is an effector of cellular contraction and a modulator of vascular permeability. Plasma 5-HIAA levels were significantly elevated in severe ARDS cases with shock status ( = 0.047) and positively correlated with SOFA ( < 0.0001) and APACHE-II score ( < 0.0001). In the longitudinal analysis, plasma 5-HIAA levels were also a strong independent predictor of mortality rate ( = 0.005). This study indicates that plasma 5-HIAA is a biomarker of ARDS severity and highlights the importance of evaluating vascular leakage levels for ARDS treatment.
急性呼吸窘迫综合征（ARDS）的特征是血管通透性失调。临床预后仍然很差，疾病负担广泛。我们证明，血清素代谢产物血浆5-羟吲哚乙酸（5-HIAA）是ARDS的关键严重程度指标。血清素是细胞收缩的效应物和血管通透性的调节剂。重度ARDS伴休克状态患者的血浆5-HIAA水平显著升高（=0.047），且与序贯器官衰竭评估（SOFA）评分（<0.0001）和急性生理与慢性健康状况评分系统II（APACHE-II）评分（<0.0001）呈正相关。在纵向分析中，血浆5-HIAA水平也是死亡率的强有力独立预测指标（=0.005）。本研究表明，血浆5-HIAA是ARDS严重程度的生物标志物，并强调了评估血管渗漏水平对ARDS治疗的重要性。
