Liu Dongyan, Wang Yanshi, Zhang Yu, Wang Haoyu, Tang Wenjuan, Duan Xiaoyu, Wang Ru, Hu Meihong, Lu Fangting, Kwak-Kim Joanne, Wu Li
Reproductive and Genetic Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China; University of Science and Technology of China, Hefei, Anhui 230026, China.
Reproductive and Genetic Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.
J Reprod Immunol. 2025 Mar;168:104429. doi: 10.1016/j.jri.2025.104429. Epub 2025 Jan 16.
Anti-phosphatidylserine/prothrombin antibodies (aPS/PT) are classified as non-criteria antiphospholipid antibodies (aPL), and are strongly associated with thrombosis and pregnancy complications linked to antiphospholipid syndrome (APS). This study aimed to investigate whether aPS/PT positivity is associated with adverse outcomes in vitro fertilization (IVF). The study included infertile women who tested positive aPS/PT and underwent IVF cycles, as well as infertile controls with pure tubal etiology. We compared the impact of aPS/PT on baseline and clinical characteristics, immune-related indicators, IVF laboratory metrics, and pregnancy outcomes. Women with aPS/PT exhibited lower numbers of retrieved oocytes, embryos, and both perfect and available embryos, as well as reduced rates of blastocyst formation. Furthermore, an imbalanced Th17/Treg ratio and significantly elevated serum IL-17A levels were observed in women with aPS/PT compared to controls. In conclusion, the presence of aPS/PT is associated with adverse IVF and pregnancy outcomes. Early screening for aPS/PT and appropriate consultation for couples undergoing IVF-ET should be considered. Additionally, specific immune and inflammatory mechanisms related to aPS/PT warrant further investigation.
抗磷脂酰丝氨酸/凝血酶原抗体（aPS/PT）被归类为非标准抗磷脂抗体（aPL），并与抗磷脂综合征（APS）相关的血栓形成和妊娠并发症密切相关。本研究旨在调查aPS/PT阳性是否与体外受精（IVF）的不良结局相关。该研究纳入了aPS/PT检测呈阳性并接受IVF周期治疗的不孕女性，以及单纯输卵管病因的不孕对照者。我们比较了aPS/PT对基线和临床特征、免疫相关指标、IVF实验室指标以及妊娠结局的影响。aPS/PT阳性的女性回收的卵母细胞、胚胎以及优质和可用胚胎的数量均较少，囊胚形成率也降低。此外，与对照组相比，aPS/PT阳性的女性Th17/Treg比例失衡，血清IL-17A水平显著升高。总之，aPS/PT的存在与IVF和妊娠的不良结局相关。应考虑对aPS/PT进行早期筛查，并对接受IVF-ET的夫妇进行适当的咨询。此外，与aPS/PT相关的特定免疫和炎症机制值得进一步研究。
