Okada Shogo, Taniguchi Masashi, Yagi Masahide, Fukumoto Yoshihiro, Hirono Tetsuya, Yamagata Momoko, Nakai Ryusuke, Kobayashi Masashi, Noriaki Ichihashi
Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Research Fellow of Japan Society for the Promotion of Science, Kojimachi Business Center Building, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Eur J Radiol. 2025 Feb;183:111930. doi: 10.1016/j.ejrad.2025.111930. Epub 2025 Jan 20.
To quantitatively verify whether degeneration in the quality of the medial femoral cartilage is correlated with muscle volume loss and intramuscular adipose tissue (IntraMAT) infiltration in quadriceps using magnetic resonance imaging (MRI).
Of the 66 older adult participants ≥60 years old (74.5 ± 6.9 years), 29 were female. All participants were patients with pre-to-mild knee osteoarthritis. Muscle volume and IntraMAT infiltration of the four individual muscles, the rectus femoris (RF), vastus medialis (VM), vastus intermedius, and vastus lateralis were assessed, using proton density-weighted and 2-point Dixon MR images. Based on the MRI T2 mapping, the T2 relaxation times of the weight-bearing surface of the medial femoral cartilage were calculated. Simple linear regression analyses were performed, evaluating the correlations between the T2 relaxation time of the medial femoral cartilage and quadriceps muscle volume and IntraMAT. Multiple linear regression analysis using a stepwise method was performed, determining which indicators of the four individual muscles correlated with cartilage quality degeneration.
Simple linear regression analyses revealed that a longer T2 relaxation time of the medial femoral cartilage was positively correlated with IntraMAT infiltration of the entire quadriceps muscle, RF, and VM, however not with the quadriceps muscle volume. Multiple linear regression analysis revealed that VM IntraMAT was particularly correlated with the extension of T2 relaxation time of the medial femoral cartilage.
In older adults with pre-to-mild knee osteoarthritis, IntraMAT infiltration of the quadriceps muscles, particularly of the VM was correlated with degeneration in the quality of the medial femoral cartilage.
使用磁共振成像（MRI）定量验证股骨内侧软骨质量退变是否与股四头肌肌肉体积减少及肌内脂肪组织（IntraMAT）浸润相关。
在66名年龄≥60岁（74.5±6.9岁）的老年参与者中，29名是女性。所有参与者均为轻度至中度膝关节骨关节炎患者。使用质子密度加权和两点 Dixon MR 图像评估股直肌（RF）、股内侧肌（VM）、股中间肌和股外侧肌这四块单独肌肉的肌肉体积和 IntraMAT 浸润情况。基于MRI T2 映射，计算股骨内侧软骨负重面的 T2 弛豫时间。进行简单线性回归分析，评估股骨内侧软骨 T2 弛豫时间与股四头肌肌肉体积和 IntraMAT 之间的相关性。使用逐步法进行多元线性回归分析，确定四块单独肌肉的哪些指标与软骨质量退变相关。
简单线性回归分析显示，股骨内侧软骨较长的 T2 弛豫时间与整个股四头肌、RF 和 VM 的 IntraMAT 浸润呈正相关，但与股四头肌肌肉体积无关。多元线性回归分析显示，VM IntraMAT 与股骨内侧软骨 T2 弛豫时间的延长尤其相关。
在轻度至中度膝关节骨关节炎的老年人中，股四头肌的 IntraMAT 浸润，尤其是 VM 的 IntraMAT 浸润与股骨内侧软骨质量退变相关。
