Abebe Koyachew Bitew
Department of Statistics, College of Natural and Computational Science, Debre Tabor University, Debre Tabor, Ethiopia.
Sci Rep. 2025 Jan 23;15(1):2940. doi: 10.1038/s41598-024-83335-1.
The human immunodeficiency virus systematically undermines the immune system, which serves as our body's inherent safeguard against diseases. Currently, it is the most serious threat to public health. Ethiopia is among the countries with the highest prevalence of HIV/AIDS. Defaulting is still a public health issue that must be resolved in order to maximize HAART's benefits. Thus, this study was aimed to assess the proportion of HAART defaulters and to identify associated factors that lead to defaulting from HAART. Data from 230 study participants was analyzed using a Cox PH regression model. The study found that patients who did not adhere to at least 95% of their regimen had a higher risk of defaulting from HAART relative to those who did adhere to at least 95% [HR = 2.924, 95% CI: 2.113, 4.047]. To advance the longevity of HIV/AIDS-infected patients within HAART medication, an intervention should be taken from the concerned body for those patients who had been at high risk of defaulting during initial and some stages of treatment. Interventions might include: following home-based treatment options; mobile health technology; granting access road facilities; accessing fast diagnostic testing procedure; giving medical advice to disclose; giving receive financial support.
人类免疫缺陷病毒系统性地破坏免疫系统，而免疫系统是我们身体抵御疾病的固有防线。目前，它是对公共卫生最严重的威胁。埃塞俄比亚是艾滋病毒/艾滋病患病率最高的国家之一。治疗中断仍然是一个公共卫生问题，必须加以解决，以便最大限度地发挥高效抗逆转录病毒治疗（HAART）的益处。因此，本研究旨在评估HAART治疗中断者的比例，并确定导致HAART治疗中断的相关因素。使用Cox PH回归模型分析了230名研究参与者的数据。研究发现，与至少坚持95%治疗方案的患者相比，未坚持至少95%治疗方案的患者有更高的HAART治疗中断风险[风险比（HR）=2.924，95%置信区间（CI）：2.113，4.047]。为了提高接受HAART药物治疗的艾滋病毒/艾滋病感染患者的寿命，对于那些在治疗初始阶段和某些阶段有高治疗中断风险的患者，相关机构应采取干预措施。干预措施可能包括：采用居家治疗方案；移动健康技术；提供交通便利；采用快速诊断检测程序；提供医疗建议以促使披露病情；提供经济支持。
