Arellano Pérez Vertti Rubén Daniel, Arellano Ramírez Daniel Orlando, González Galarza Faviel Francisco, Prieto Hinojosa Adria Imelda, Méndez Hernández Alejandra, Muñoz Flores Myrna Vianney, Arellano Ramírez Diego Fernando, Argüello Beltrán Cristina Sofía, Argüello Astorga Rafael
Department of Orthopedics, Faculty of Medicine Torreón, Autonomous University of Coahuila, Primero de Cobián Centro, Av Morelos 900-Oriente, 27000, Torreón, Coahuila, México.
Department of Molecular Immunobiology, Autonomous University of Coahuila, Biomedical Research Center Torreón, Tercero de Cobián Centro, Gregorio A. García 198, 27000, Torreón, Coahuila, México.
Clin Rheumatol. 2025 Mar;44(3):1329-1335. doi: 10.1007/s10067-025-07332-z. Epub 2025 Jan 23.
Vitamin D deficiency is a public health problem worldwide. Some studies have associated serum vitamin D deficiency with knee osteoarthritis. Additionally, some vitamin D receptor polymorphisms have been linked to knee osteoarthritis. This study analyzed the associations among the rs731236 polymorphism of the vitamin D receptor, blood levels of vitamin D and primary knee osteoarthritis in a population from northern Mexico. A case‒control study was conducted from November 2023 to June 2024 with 449 unrelated participants. The vitamin D concentration in the blood was measured semiquantitatively. The presence of vitamin D receptor gene polymorphism genotypes (rs731236) was determined via the rhAmpTM SNP Assay methodology. We used the chi-square test to compare the groups and odds ratios with confidence intervals to calculate risk. In the presence of vitamin D deficiency, subjects showed a 1.5-fold increased risk of primary knee osteoarthritis (59.5%; p = 0.001). Notably, this association remained significant for subjects carrying the AA and AG genotypes and in a dominant model (60.0%, p = 0.023; 61.1%, p = 0.008 and 59.0%, p = 0.042, respectively), after including a multivariate association model. Our study identified a high prevalence of Vitamin D deficiency among individuals with primary knee osteoarthritis. This study suggests a potential association between deficient levels of vitamin D and primary KOA in carriers of the AA and AG rs731236 genotypes. Key Points • We observed a significant 1.5-fold increased risk of primary knee osteoarthritis in the presence of vitamin D deficiency. • Vitamin D deficiency is significantly associated with primary knee osteoarthritis in carriers of AA and AG genotypes of rs73123.
维生素D缺乏是一个全球性的公共卫生问题。一些研究已将血清维生素D缺乏与膝关节骨关节炎联系起来。此外，一些维生素D受体基因多态性也与膝关节骨关节炎有关。本研究分析了墨西哥北部人群中维生素D受体的rs731236多态性、维生素D血液水平与原发性膝关节骨关节炎之间的关联。2023年11月至2024年6月进行了一项病例对照研究，共有449名无亲属关系的参与者。采用半定量方法测定血液中的维生素D浓度。通过rhAmpTM SNP检测方法确定维生素D受体基因多态性基因型（rs731236）的存在情况。我们使用卡方检验比较各组，并计算比值比及置信区间以评估风险。在存在维生素D缺乏的情况下，受试者患原发性膝关节骨关节炎的风险增加了1.5倍（59.5%；p = 0.001）。值得注意的是，在纳入多变量关联模型后，对于携带AA和AG基因型的受试者以及显性模型，这种关联仍然显著（分别为60.0%，p = 0.023；61.1%，p = 0.008和59.0%，p = 0.042）。我们的研究发现原发性膝关节骨关节炎患者中维生素D缺乏的患病率很高。本研究表明，AA和AG rs731236基因型携带者的维生素D水平不足与原发性膝关节骨关节炎之间可能存在关联。要点：• 我们观察到在存在维生素D缺乏的情况下，原发性膝关节骨关节炎的风险显著增加了1.5倍。• rs73123的AA和AG基因型携带者中，维生素D缺乏与原发性膝关节骨关节炎显著相关。
