Department of Medical Biology, Faculty of Medicine, Near East University, 99138, Nicosia, Cyprus.
Research Center of Experimental Health Sciences (DESAM), Near East University, 99138, Nicosia, Cyprus.
Mol Biol Rep. 2019 Jun;46(3):3349-3355. doi: 10.1007/s11033-019-04796-6. Epub 2019 Apr 12.
Vitamin D is an important molecule to keep teeth, bones and muscles healthy. It is obtained from diet, supplements and primarily from exposure to sunlight. In recent years, vitamin D deficiency is recognised as a worldwide health problem, which results in disturbances in mineral metabolism and skeletal problems. Deficiency might be caused due to sedentary lifestyle, insufficient diet, age as well as some polymorphisms in the VDR gene. In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. The rs2228570 (FokI) variant but not others were shown to have a significant association with decreased serum vitamin D levels in the Turkish Cypriot population.
维生素 D 是维持牙齿、骨骼和肌肉健康的重要分子。它可以通过饮食、补充剂和主要通过暴露在阳光下获得。近年来，维生素 D 缺乏被认为是一个全球性的健康问题，导致矿物质代谢紊乱和骨骼问题。缺乏可能是由于久坐的生活方式、饮食不足、年龄以及 VDR 基因中的一些多态性引起的。在这项研究中，研究了土耳其塞浦路斯人队列中最常见的四种 VDR 多态性（rs1544410（BsmI）、rs731236（TaqI）、rs7975232（ApaI）和 rs2228570（FokI）），并旨在检测低血清维生素 D 水平与这些变体之间的任何可能联系。结果显示，rs2228570（FokI）变体而非其他变体与土耳其塞浦路斯人血清维生素 D 水平降低有显著相关性。
