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一个被揭示的无声威胁:一名腹膜透析患者的戈登分枝杆菌导管相关性腹膜炎

A Silent Threat Unveiled: Mycobacterium gordonae Catheter-Related Peritonitis in a Patient on Peritoneal Dialysis.

作者信息

Hein Min Aung, Parinyasiri Uraiwan, Wannigama Dhammika Lehan, Udomsantisuk Nibondh, Kanjanabuch Talerngsak

机构信息

Department of Nephrology, No. (1) 1000-Bedded Defence Services General Hospital, Yangon, MMR.

Kidney Diseases Clinic, Department of Internal Medicines, Songkhla Hospital, Songkhla, THA.

出版信息

Cureus. 2024 Dec 23;16(12):e76280. doi: 10.7759/cureus.76280. eCollection 2024 Dec.

DOI:10.7759/cureus.76280
PMID:39850194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11753903/
Abstract

Infectious complications in peritoneal dialysis (PD) remain a constant challenge, with atypical pathogens posing significant risks. This case from Thailand highlights the rare occurrence of , an often-overlooked non-tuberculous mycobacterium (NTM), as the causative agent in a catheter-related exit-site infection that progressed to peritonitis. Initially misattributed to  from preceding exit-site infections, was ultimately identified as the primary pathogen through multiple effluent cultures and advance polymerase chain reaction sequencing. This case underscores the importance of heightened clinical suspicion, early and accurate diagnosis, and timely interventions to prevent severe complications, including hemodialysis transfer.

摘要

腹膜透析(PD)中的感染并发症仍然是一个持续存在的挑战,非典型病原体带来重大风险。这个来自泰国的病例突出了一种常被忽视的非结核分枝杆菌(NTM)——[此处原文缺失具体菌名]罕见地作为导管相关出口部位感染并进展为腹膜炎的病原体。最初因先前出口部位感染而被误诊为[此处原文缺失具体菌名],最终通过多次腹水培养和先进的聚合酶链反应测序确定[此处原文缺失具体菌名]为主要病原体。该病例强调了提高临床怀疑、早期准确诊断以及及时干预以预防严重并发症(包括转为血液透析)的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/841e/11753903/c6f90c9160f9/cureus-0016-00000076280-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/841e/11753903/c6f90c9160f9/cureus-0016-00000076280-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/841e/11753903/c6f90c9160f9/cureus-0016-00000076280-i01.jpg

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本文引用的文献

1
ISPD Catheter-related Infection Recommendations: 2023 Update.国际腹膜透析学会导管相关性感染推荐:2023 更新版。
Perit Dial Int. 2023 May;43(3):201-219. doi: 10.1177/08968608231172740. Epub 2023 May 26.
2
Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS).丝状真菌引起的腹膜透析相关感染的预测因素和结果(MycoPDICS)。
PLoS One. 2022 May 24;17(5):e0268823. doi: 10.1371/journal.pone.0268823. eCollection 2022.
3
ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.
国际腹膜透析学会(ISPD)腹膜炎指南建议:2022年预防与治疗更新版
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Nontuberculous mycobacteria infections of peritoneal dialysis patients: A multicenter study.腹膜透析患者非结核分枝杆菌感染:一项多中心研究。
Perit Dial Int. 2021 May;41(3):284-291. doi: 10.1177/0896860820923461. Epub 2020 May 13.
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Determinants of peritoneal dialysis technique failure in incident US patients.美国新进入腹膜透析患者腹膜透析技术失败的决定因素。
Perit Dial Int. 2013 Mar-Apr;33(2):155-66. doi: 10.3747/pdi.2011.00233. Epub 2012 Oct 2.
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Peritoneal dialysis-associated nontuberculous mycobacterium peritonitis: a systematic review of reported cases.与腹膜透析相关的非结核分枝杆菌性腹膜炎:已报告病例的系统综述。
Nephrol Dial Transplant. 2012 Apr;27(4):1639-44. doi: 10.1093/ndt/gfr504. Epub 2011 Sep 2.
8
Successful treatment of Mycobacterium gordonae exit-site and tunnel infection by partial catheter reimplantation of the Tenckhoff catheter.通过Tenckhoff导管部分重新植入成功治疗戈登分枝杆菌出口部位和隧道感染。
Perit Dial Int. 2011 May-Jun;31(3):368-70. doi: 10.3747/pdi.2010.00222.
9
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.美国胸科学会/美国感染病学会官方声明:非结核分枝杆菌病的诊断、治疗与预防
Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416. doi: 10.1164/rccm.200604-571ST.
10
Change in bacterial aetiology of peritoneal dialysis-related peritonitis over 10 years: experience from a centre in South-East Asia.10年间腹膜透析相关腹膜炎细菌病因的变化:来自东南亚某中心的经验
Clin Microbiol Infect. 2005 Oct;11(10):837-9. doi: 10.1111/j.1469-0691.2005.01222.x.