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伴有急性神经认知障碍的重症诺氏疟:一例报告。

Severe knowlesi malaria with acute neurocognitive impairment: A case report.

作者信息

Gunawan Carta Agrawanto

机构信息

Division of Infectious Disease and Tropical Medicine, Department of Internal Medicine, Abdoel Wahab Sjahranie General Hospital/Mulawarman University Faculty of Medicine, Samarinda, Indonesia.

出版信息

IJID Reg. 2024 Dec 6;14:100513. doi: 10.1016/j.ijregi.2024.100513. eCollection 2025 Mar.

DOI:10.1016/j.ijregi.2024.100513
PMID:39850332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11754819/
Abstract

infection in Indonesia has been reported from Sumatera and Kalimantan Island. has the shortest asexual replication cycle of all species, leading to rapidly increased parasitemia levels; however, it usually does not cause high parasitemia. It was reported a severe knowlesi malaria case in a 41-year-old male patient in Samarinda, East Kalimantan Province, Indonesia. The patient was admitted to the hospital with fever and decrease in level of consciousness. Malarial blood smear showed trophozoites and ring forms of with parasite count 52,000/µl blood, and confirmed by polymerase chain reaction test. The patient was diagnosed as having severe knowlesi malaria with a high parasitemia level, accompanied by acute neurocognitive impairments, including moderate weakness, disorientation, and partial loss of memory that lasted for approximately 3 weeks.

摘要

印度尼西亚的苏门答腊岛和加里曼丹岛已报告有感染病例。[该物种]在所有物种中具有最短的无性繁殖周期,导致寄生虫血症水平迅速上升;然而,它通常不会引起高寄生虫血症。据报道,在印度尼西亚东加里曼丹省三马林达市的一名41岁男性患者中出现了一例严重的诺氏疟疾病例。该患者因发热和意识水平下降入院。疟原虫血涂片显示有滋养体和环状体,每微升血液中的寄生虫计数为52,000个,并通过聚合酶链反应试验得到确诊。该患者被诊断为患有高寄生虫血症水平的严重诺氏疟疾病例,伴有急性神经认知障碍,包括中度虚弱、定向障碍和部分记忆丧失,持续了大约3周。 (注:原文中“ has the shortest asexual replication cycle of all species”这里的“ has”前缺少主语,根据语境推测可能是某一物种,但无法准确得知,故翻译时保留英文表述。)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84f/11754819/55c59e3a2033/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84f/11754819/55c59e3a2033/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84f/11754819/55c59e3a2033/gr1.jpg

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本文引用的文献

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Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology.疟原虫 Knowlesi:人类风险因素、临床谱和病理生理学。
Adv Parasitol. 2021;113:1-43. doi: 10.1016/bs.apar.2021.08.001. Epub 2021 Aug 28.
3
Plasmodium knowlesi infecting humans in Southeast Asia: What's next?东南亚地区出现感染人类的疟原虫 knowlesi:接下来会怎样?
PLoS Negl Trop Dis. 2020 Dec 31;14(12):e0008900. doi: 10.1371/journal.pntd.0008900. eCollection 2020 Dec.
4
Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species.2015 - 2017年马来西亚沙巴州诺氏疟原虫疟疾:尽管仅感染人类的疟原虫种类已接近消除,但发病率仍在持续上升。
Clin Infect Dis. 2020 Jan 16;70(3):361-367. doi: 10.1093/cid/ciz237.
5
Age-Related Clinical Spectrum of Plasmodium knowlesi Malaria and Predictors of Severity.年龄相关性 knowlesi 疟原虫疟疾的临床谱及严重程度的预测因素。
Clin Infect Dis. 2018 Jul 18;67(3):350-359. doi: 10.1093/cid/ciy065.
6
A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy.一项在马来西亚沙巴州进行的关于诺氏疟原虫、恶性疟原虫和间日疟原虫的前瞻性对比研究:来自诺氏疟原虫和间日疟原虫的严重疾病比例较高,但如果早期转诊和使用青蒿琥酯治疗则无死亡。
Clin Infect Dis. 2013 Feb;56(3):383-97. doi: 10.1093/cid/cis902. Epub 2012 Oct 19.