携带β-内酰胺酶的高危克隆：2024年更新
High-risk clones harboring β-lactamases: 2024 update.
作者信息
Flores-Vega Verónica Roxana, Partida-Sanchez Santiago, Ares Miguel A, Ortiz-Navarrete Vianney, Rosales-Reyes Roberto
机构信息
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
出版信息
Heliyon. 2024 Dec 26;11(1):e41540. doi: 10.1016/j.heliyon.2024.e41540. eCollection 2025 Jan 15.
Abstract
Carbapenem-resistant is defined by the World Health Organization as a "high priority" in developing new antimicrobials. Indeed, the emergence and spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacteria increase the morbidity and mortality risk of infected patients. Genomic variants of that display phenotypes of MDR/XDR have been defined as high-risk global clones. In this mini-review, we describe some international high-risk clones that carry β-lactamase genes that can produce chronic colonization and increase infected patients' morbidity and mortality rates.
摘要
世界卫生组织将耐碳青霉烯类定义为开发新型抗菌药物中的“高度优先事项”。确实，多重耐药（MDR）或广泛耐药（XDR）细菌的出现和传播增加了感染患者的发病和死亡风险。表现出MDR/XDR表型的[细菌名称未给出]基因组变体已被定义为全球高危克隆。在本小型综述中，我们描述了一些携带β-内酰胺酶基因的国际高危克隆，这些基因可导致慢性定植并增加感染患者的发病率和死亡率。
相似文献
1
High-risk clones harboring β-lactamases: 2024 update.携带β-内酰胺酶的高危克隆：2024年更新
Heliyon. 2024 Dec 26;11(1):e41540. doi: 10.1016/j.heliyon.2024.e41540. eCollection 2025 Jan 15.
2
Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired β-lactamases: 2020 update.铜绿假单胞菌流行高危克隆及其与水平获得性β-内酰胺酶的关系：2020 年更新。
Int J Antimicrob Agents. 2020 Dec;56(6):106196. doi: 10.1016/j.ijantimicag.2020.106196. Epub 2020 Oct 9.
3
Current trends in the epidemiology of multidrug-resistant and beta-lactamase-producing in Asia and Africa: a systematic review and meta-analysis.亚洲和非洲耐多药及产β-内酰胺酶细菌的流行病学现状：一项系统评价与荟萃分析
PeerJ. 2025 Feb 24;13:e18986. doi: 10.7717/peerj.18986. eCollection 2025.
4
The increasing threat of Pseudomonas aeruginosa high-risk clones.铜绿假单胞菌高危克隆的威胁日益增加。
Drug Resist Updat. 2015 Jul-Aug;21-22:41-59. doi: 10.1016/j.drup.2015.08.002. Epub 2015 Aug 10.
5
Import of global high-risk clones is the primary driver of carbapenemase-producing in Norway.全球高危克隆株的引入是挪威产碳青霉烯酶菌株产生的主要驱动因素。
J Med Microbiol. 2025 Jan;74(1). doi: 10.1099/jmm.0.001944.
6
Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals.爱沙尼亚医院的多重耐药铜绿假单胞菌。
BMC Infect Dis. 2018 Oct 11;18(1):513. doi: 10.1186/s12879-018-3421-1.
7
Distribution of Pseudomonas-Derived Cephalosporinase and Metallo-β-Lactamases in Carbapenem-Resistant Pseudomonas aeruginosa Isolates from Korea.韩国碳青霉烯耐药铜绿假单胞菌分离株中假单胞菌衍生头孢菌素酶和金属β-内酰胺酶的分布
J Microbiol Biotechnol. 2015 Jul;25(7):1154-62. doi: 10.4014/jmb.1503.03065.
8
Characterization and genetic analysis of extensively drug-resistant hospital acquired Pseudomonas aeruginosa isolates.广泛耐药医院获得性铜绿假单胞菌分离株的特征和遗传分析。
BMC Microbiol. 2024 Jun 26;24(1):225. doi: 10.1186/s12866-024-03321-5.
9
High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Clinical Isolates from a Tertiary Care Hospital in Egypt.埃及一家三级护理医院耐多药和广泛耐药临床分离株中与金属β-内酰胺酶相关的氨基糖苷类甲基转移酶高发生率
Infect Drug Resist. 2021 Nov 19;14:4849-4858. doi: 10.2147/IDR.S335582. eCollection 2021.
10
Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones.广泛泛耐药铜绿假单胞菌高危克隆的遗传标记。
Antimicrob Agents Chemother. 2012 Dec;56(12):6349-57. doi: 10.1128/AAC.01388-12. Epub 2012 Oct 8.
引用本文的文献
1
Characterization of by Whole-Genome Sequencing from a Clinical Sample: New Challenges in Identification.通过临床样本全基因组测序对[具体内容缺失]进行特征分析：鉴定中的新挑战
Reports (MDPI). 2025 Jul 3;8(3):104. doi: 10.3390/reports8030104.
2
Carbapenem-Resistant Resistome: Pan-Genomic Plasticity, the Impact of Transposable Elements and Jumping Genes.耐碳青霉烯类耐药基因组：泛基因组可塑性、转座元件和跳跃基因的影响
Antibiotics (Basel). 2025 Mar 31;14(4):353. doi: 10.3390/antibiotics14040353.
本文引用的文献
1
Prevalence of colistin resistance in clinical isolates of : a systematic review and meta-analysis.临床分离株中黏菌素耐药性的流行情况：一项系统评价和荟萃分析。
Front Microbiol. 2024 Oct 9;15:1477836. doi: 10.3389/fmicb.2024.1477836. eCollection 2024.
2
Genetic Alternatives for Experimental Adaptation to Colistin in Three Lineages.用于三个谱系中对黏菌素进行实验性适应性的遗传替代方案。
Antibiotics (Basel). 2024 May 15;13(5):452. doi: 10.3390/antibiotics13050452.
3
Genome analyses of colistin-resistant high-risk bla producing Klebsiella pneumoniae ST147 and Pseudomonas aeruginosa ST235 and ST357 in clinical settings.临床环境中产高风险 bla 碳青霉烯酶的耐药肺炎克雷伯菌 ST147 和铜绿假单胞菌 ST235 和 ST357 的基因组分析。
BMC Microbiol. 2024 May 20;24(1):174. doi: 10.1186/s12866-024-03306-4.
4
Nationwide genome surveillance of carbapenem-resistant in Japan.日本全国范围内耐碳青霉烯类肠杆菌科细菌的基因组监测。
Antimicrob Agents Chemother. 2024 May 2;68(5):e0166923. doi: 10.1128/aac.01669-23. Epub 2024 Apr 2.
5
Spread of ST274 Clone in Different Niches: Resistome, Virulome, and Phylogenetic Relationship.ST274克隆在不同生态位中的传播：耐药基因组、病毒组及系统发育关系
Antibiotics (Basel). 2023 Oct 24;12(11):1561. doi: 10.3390/antibiotics12111561.
6
Antimicrobial Resistance, Genetic Lineages, and Biofilm Formation in Isolated from Human Infections: An Emerging One Health Concern.从人类感染中分离出的[微生物名称未给出]的抗菌药物耐药性、遗传谱系和生物膜形成：一个新出现的“同一健康”问题 。 （注：原文中“Isolated from Human Infections”前似乎缺少具体的微生物名称）
Antibiotics (Basel). 2023 Jul 29;12(8):1248. doi: 10.3390/antibiotics12081248.
7
Endemicity of producing IMP-18 and/or VIM-2 MBLs from the high-risk clone ST111 in Central America.在中美洲，高风险克隆株ST111产生IMP-18和/或VIM-2金属β-内酰胺酶的地方性流行情况。
JAC Antimicrob Resist. 2023 Aug 1;5(4):dlad092. doi: 10.1093/jacamr/dlad092. eCollection 2023 Aug.
8
Emergence of ST463 -Positive, Imipenem-Nonsusceptible Pseudomonas aeruginosa Isolates in China.中国出现耐亚胺培南铜绿假单胞菌 ST463 阳性分离株。
Microbiol Spectr. 2023 Aug 17;11(4):e0010523. doi: 10.1128/spectrum.00105-23. Epub 2023 Jun 14.
9
Evolving landscape of carbapenem-resistant at a single centre in the USA.美国一个单一中心耐碳青霉烯类药物情况的演变
JAC Antimicrob Resist. 2023 Jun 3;5(3):dlad070. doi: 10.1093/jacamr/dlad070. eCollection 2023 Jun.
10
Whole-genome sequencing reveals high-risk clones of in Guangdong, China.全基因组测序揭示了中国广东[具体物种或疾病等，原文未完整给出]的高风险克隆。
Front Microbiol. 2023 Apr 14;14:1117017. doi: 10.3389/fmicb.2023.1117017. eCollection 2023.
Zotero 插件