Flores-Vega Verónica Roxana, Partida-Sanchez Santiago, Ares Miguel A, Ortiz-Navarrete Vianney, Rosales-Reyes Roberto
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
Heliyon. 2024 Dec 26;11(1):e41540. doi: 10.1016/j.heliyon.2024.e41540. eCollection 2025 Jan 15.
Carbapenem-resistant is defined by the World Health Organization as a "high priority" in developing new antimicrobials. Indeed, the emergence and spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacteria increase the morbidity and mortality risk of infected patients. Genomic variants of that display phenotypes of MDR/XDR have been defined as high-risk global clones. In this mini-review, we describe some international high-risk clones that carry β-lactamase genes that can produce chronic colonization and increase infected patients' morbidity and mortality rates.
世界卫生组织将耐碳青霉烯类定义为开发新型抗菌药物中的“高度优先事项”。确实，多重耐药（MDR）或广泛耐药（XDR）细菌的出现和传播增加了感染患者的发病和死亡风险。表现出MDR/XDR表型的[细菌名称未给出]基因组变体已被定义为全球高危克隆。在本小型综述中，我们描述了一些携带β-内酰胺酶基因的国际高危克隆，这些基因可导致慢性定植并增加感染患者的发病率和死亡率。
